In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis.
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| Title: | In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis. |
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| Authors: | Gacem N; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Bezukladova S; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy., Windener F; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany., Karam T; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Ottoboni L; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy., Brambilla E; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy., Ruffini F; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy., Soman K; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA., Garcia-Diaz B; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Levy MJF; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Cui QL; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada., Formato A; Department of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy., Deboux C; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Chazot J; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Panic R; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Albrecht S; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany., Yilmaz EN; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany., González RG; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany., Eberini I; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy., Olla S; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042 Monserrato, Italy., Bresciani A; IRBM S.p.A., Pomezia, Rome 00071, Italy., Goebels N; Department of Neurology, Medical Faculty, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany., Zipp F; Department of Neurology, Focus Program Translational Neuroscience and Immunotherapy, Rhine-Main Neuroscience Network, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany., Agresti C; Department of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy., Antel J; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada., Evercooren AB; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Kuhlmann T; Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany., Baranzini SE; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA., Panina-Bordignon P; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy., Nait-Oumesmar B; Paris Brain Institute - Institut du Cerveau (ICM), Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France., Martino G; Division of Neuroscience, Vita-Salute San Raffaele University, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, 20129 Milan, Italy. |
| Source: | Science translational medicine [Sci Transl Med] 2026 Jan 21; Vol. 18 (833), pp. eads0633. Date of Electronic Publication: 2026 Jan 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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