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Anti-FAP CAR T cells produced in vivo reduce fibrosis and restore liver homeostasis in metabolic dysfunction-associated steatohepatitis.

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Title: Anti-FAP CAR T cells produced in vivo reduce fibrosis and restore liver homeostasis in metabolic dysfunction-associated steatohepatitis.
Authors: Yashaswini CN; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Medical Scientist Training Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Cogliati B; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, Brazil., Qin T; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., To T; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Williamson T; Department of Cell and Developmental Biology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.; Penn Cardiovascular Institute, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.; Institute for Regenerative Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA., Papp TE; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA., Li K; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Medical Scientist Training Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rasul R; Pharmanest Inc., Princeton, NJ 08540, USA., Chen L; Pharmanest Inc., Princeton, NJ 08540, USA., Lightstone A; Pharmanest Inc., Princeton, NJ 08540, USA., Aghajanian H; Department of Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.; Capstan Therapeutics Inc., San Diego, CA 92121, USA., Parhiz H; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA., Wang S; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rurik JG; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm 141 52, Sweden., Epstein JA; Department of Cell and Developmental Biology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.; Penn Cardiovascular Institute, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.; Institute for Regenerative Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA., Friedman SL; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Jan 21; Vol. 18 (833), pp. eadx0368. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Anti-FAP CAR T cells produced in vivo reduce fibrosis and restore liver homeostasis in metabolic dysfunction-associated steatohepatitis.
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  Data: <searchLink fieldCode="AU" term="%22Yashaswini+CN%22">Yashaswini CN</searchLink>; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Medical Scientist Training Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Cogliati+B%22">Cogliati B</searchLink>; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, Brazil.<br /><searchLink fieldCode="AU" term="%22Qin+T%22">Qin T</searchLink>; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22To+T%22">To T</searchLink>; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Williamson+T%22">Williamson T</searchLink>; Department of Cell and Developmental Biology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.; Penn Cardiovascular Institute, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.; Institute for Regenerative Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Papp+TE%22">Papp TE</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Li+K%22">Li K</searchLink>; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Medical Scientist Training Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Rasul+R%22">Rasul R</searchLink>; Pharmanest Inc., Princeton, NJ 08540, USA.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Pharmanest Inc., Princeton, NJ 08540, USA.<br /><searchLink fieldCode="AU" term="%22Lightstone+A%22">Lightstone A</searchLink>; Pharmanest Inc., Princeton, NJ 08540, USA.<br /><searchLink fieldCode="AU" term="%22Aghajanian+H%22">Aghajanian H</searchLink>; Department of Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.; Capstan Therapeutics Inc., San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Parhiz+H%22">Parhiz H</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Rurik+JG%22">Rurik JG</searchLink>; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm 141 52, Sweden.<br /><searchLink fieldCode="AU" term="%22Epstein+JA%22">Epstein JA</searchLink>; Department of Cell and Developmental Biology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.; Penn Cardiovascular Institute, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.; Institute for Regenerative Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Friedman+SL%22">Friedman SL</searchLink>; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
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