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Phase I Clinical Trial of Islet Antigen-Specific Plasmid Coexpressing Tolerogenic Proteins Demonstrates Safety in Adults With Type 1 Diabetes.

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Title: Phase I Clinical Trial of Islet Antigen-Specific Plasmid Coexpressing Tolerogenic Proteins Demonstrates Safety in Adults With Type 1 Diabetes.
Authors: Greenbaum CJ; Center for Interventional Immunology, Benaroya Research Institute, Seattle, WA., Long SA; Center for Translational Immunology, Benaroya Research Institute, Seattle, WA., Gitelman SE; University of California, San Francisco, San Francisco, CA., Gaglia JL; Joslin Diabetes Center, Harvard Medical School, Boston, MA., Daniels M; Division of Endocrinology and Diabetes, Children's Hospital of Orange County, Orange, CA., Brusko TM; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL., Lord S; Center for Interventional Immunology, Benaroya Research Institute, Seattle, WA., Bundy BN; Health Informatics Institute, University of South Florida, Tampa, FL., Krischer JP; Health Informatics Institute, University of South Florida, Tampa, FL., Haller MJ; Department of Pediatrics, Diabetes Institute, College of Medicine, University of Florida, Gainesville, FL., Steck AK; Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO., DiMeglio LA; Division of Pediatric Endocrinology and Diabetology, Department of Pediatrics, Indiana University, Indianapolis, IN., Evans-Molina C; Division of Pediatric Endocrinology and Diabetology, Department of Pediatrics, Indiana University, Indianapolis, IN., Moran A; Department of Pediatrics, University of Minnesota, Minneapolis, MN., Prahalad P; Division of Endocrinology and Diabetes, Department of Pediatrics, Stanford University, Stanford, CA., Wilson DM; Division of Endocrinology and Diabetes, Department of Pediatrics, Stanford University, Stanford, CA., Russell WE; Departments of Pediatrics and Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN., Sherr JL; Division of Pediatric Endocrinology, Yale University School of Medicine, New Haven, CT., Raskin P; Department of Pediatrics, University of Texas Southwestern, Dallas, TX., Clements MA; Division of Pediatric Endocrinology, Children's Mercy Hospital, University of Missouri-Kansas City, Kansas City, MO., Moore WV; Division of Pediatric Endocrinology, Children's Mercy Hospital, University of Missouri-Kansas City, Kansas City, MO., Libman I; Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA., Wassermann K; Novo Nordisk A/S, Søborg, Denmark., von Herrath M; Novo Nordisk A/S, Søborg, Denmark., Bergholdt R; Novo Nordisk A/S, Søborg, Denmark., Hastrup H; Novo Nordisk A/S, Søborg, Denmark., Kobernat SE; Center for Translational Immunology, Benaroya Research Institute, Seattle, WA., Kus AM; Center for Translational Immunology, Benaroya Research Institute, Seattle, WA., Tung LW; Center for Systems Biology, Benaroya Research Institute, Seattle, WA., Goland RS; Departments of Medicine and Pediatrics, Columbia University, New York, NY., Herold KC; Departments of Immunobiology and Internal Medicine, Yale University, New Haven, CT.
Corporate Authors: Type 1 Diabetes TrialNet Study Group*
Source: Diabetes [Diabetes] 2026 Mar 01; Vol. 75 (3), pp. 506-518.
Publication Type: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial
Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase I Clinical Trial of Islet Antigen-Specific Plasmid Coexpressing Tolerogenic Proteins Demonstrates Safety in Adults With Type 1 Diabetes.
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  Data: <searchLink fieldCode="CA" term="%22Type+1+Diabetes+TrialNet+Study+Group*%22">Type 1 Diabetes TrialNet Study Group*</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220372763%22">Diabetes</searchLink> [Diabetes] 2026 Mar 01; Vol. 75 (3), pp. 506-518.
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  Data: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Diabetes+Association%22">American Diabetes Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372763 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1939-327X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200121797%22">00121797 </searchLink><i>NLM ISO Abbreviation: </i>Diabetes <i>Subsets: </i>MEDLINE
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