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Endothelial cell responses in sepsis are attenuated by targeting truncated procalcitonin.

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Title: Endothelial cell responses in sepsis are attenuated by targeting truncated procalcitonin.
Authors: Brabenec L; University Hospital Münster, Department of Anaesthesiology, Intensive Care and Pain Medicine, Münster, Germany.; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Hellenthal KE; University Hospital Münster, Department of Anaesthesiology, Intensive Care and Pain Medicine, Münster, Germany.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Kintrup S; University Hospital Münster, Department of Anaesthesiology, Intensive Care and Pain Medicine, Münster, Germany., Cyran L; University Hospital Würzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Würzburg, Germany., Burkard P; University Hospital Würzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Würzburg, Germany., Nottebaum A; Max-Planck Institute of Molecular Biomedicine, Department of Vascular Cell Biology, Münster, Germany., Schughart K; University of Münster, Institute of Virology, Münster, Germany.; University of Tennessee Health Science Center, Department of Microbiology, Immunology and Biochemistry, Memphis, TN, USA., Wagner S; University of Birmingham, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, Birmingham, UK., Arnold R; University of Birmingham, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, Birmingham, UK., Rauschenberger V; University Hospital Würzburg, Institute for Hygiene and Microbiology, Würzburg, Germany., Kampmeier S; University Hospital Würzburg, Institute for Hygiene and Microbiology, Würzburg, Germany.; University Hospital Würzburg, Infection Control and Antimicrobial Stewardship Unit, Würzburg, Germany., Meybohm P; University Hospital Würzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Würzburg, Germany., Schlegel N; University Hospital Würzburg, Department of General, Visceral, Transplantation, Vascular and Paediatric Surgery (Department of Surgery I), Würzburg, Germany., Vestweber D; Max-Planck Institute of Molecular Biomedicine, Department of Vascular Cell Biology, Münster, Germany., Wagner NM; University Hospital Würzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Würzburg, Germany. nmwagner@uni-mainz.de.; Department of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. nmwagner@uni-mainz.de.
Source: Nature communications [Nat Commun] 2026 Jan 21; Vol. 17 (1), pp. 827. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Endothelial cell responses in sepsis are attenuated by targeting truncated procalcitonin.
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  Data: <searchLink fieldCode="AU" term="%22Brabenec+L%22">Brabenec L</searchLink>; University Hospital Münster, Department of Anaesthesiology, Intensive Care and Pain Medicine, Münster, Germany.; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Hellenthal+KE%22">Hellenthal KE</searchLink>; University Hospital Münster, Department of Anaesthesiology, Intensive Care and Pain Medicine, Münster, Germany.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kintrup+S%22">Kintrup S</searchLink>; University Hospital Münster, Department of Anaesthesiology, Intensive Care and Pain Medicine, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Cyran+L%22">Cyran L</searchLink>; University Hospital Würzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Burkard+P%22">Burkard P</searchLink>; University Hospital Würzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Nottebaum+A%22">Nottebaum A</searchLink>; Max-Planck Institute of Molecular Biomedicine, Department of Vascular Cell Biology, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Schughart+K%22">Schughart K</searchLink>; University of Münster, Institute of Virology, Münster, Germany.; University of Tennessee Health Science Center, Department of Microbiology, Immunology and Biochemistry, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Wagner+S%22">Wagner S</searchLink>; University of Birmingham, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Arnold+R%22">Arnold R</searchLink>; University of Birmingham, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Rauschenberger+V%22">Rauschenberger V</searchLink>; University Hospital Würzburg, Institute for Hygiene and Microbiology, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kampmeier+S%22">Kampmeier S</searchLink>; University Hospital Würzburg, Institute for Hygiene and Microbiology, Würzburg, Germany.; University Hospital Würzburg, Infection Control and Antimicrobial Stewardship Unit, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Meybohm+P%22">Meybohm P</searchLink>; University Hospital Würzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schlegel+N%22">Schlegel N</searchLink>; University Hospital Würzburg, Department of General, Visceral, Transplantation, Vascular and Paediatric Surgery (Department of Surgery I), Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vestweber+D%22">Vestweber D</searchLink>; Max-Planck Institute of Molecular Biomedicine, Department of Vascular Cell Biology, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+NM%22">Wagner NM</searchLink>; University Hospital Würzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Würzburg, Germany. nmwagner@uni-mainz.de.; Department of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. nmwagner@uni-mainz.de.
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