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Biological insights into schizophrenia from ancestrally diverse populations.

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Title: Biological insights into schizophrenia from ancestrally diverse populations.
Authors: Bigdeli TB; VA New York Harbor Healthcare System, New York, NY, USA. tim.bigdeli@va.gov.; Institute for Genomics in Health (IGH), SUNY Downstate Health Sciences University, New York, NY, USA. tim.bigdeli@va.gov.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, New York, NY, USA. tim.bigdeli@va.gov.; Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, New York, NY, USA. tim.bigdeli@va.gov., Chatzinakos C; Institute for Genomics in Health (IGH), SUNY Downstate Health Sciences University, New York, NY, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, New York, NY, USA., Bendl J; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Barr PB; VA New York Harbor Healthcare System, New York, NY, USA.; Institute for Genomics in Health (IGH), SUNY Downstate Health Sciences University, New York, NY, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, New York, NY, USA.; Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, New York, NY, USA., Venkatesh S; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Precision Medicine and Translational Therapeutics, James J. Peters VA Medical Center, New York, NY, USA., Gorman BR; Massachusetts Area Veterans Epidemiology Research and Information Center (MAVERIC), Boston, MA, USA., Clarence T; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Genovese G; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Iyegbe CO; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Peterson RE; VA New York Harbor Healthcare System, New York, NY, USA.; Institute for Genomics in Health (IGH), SUNY Downstate Health Sciences University, New York, NY, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, New York, NY, USA., Kolokotronis SO; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, New York, NY, USA.; Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, College of Medicine, SUNY Downstate Health Sciences University, New York, NY, USA.; Department of Cell Biology, College of Medicine, SUNY Downstate Health Sciences University, New York, NY, USA., Burstein D; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Precision Medicine and Translational Therapeutics, James J. Peters VA Medical Center, New York, NY, USA.; VISN2 Mental Illness Research, Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, New York, NY, USA., Meyers JL; Institute for Genomics in Health (IGH), SUNY Downstate Health Sciences University, New York, NY, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, New York, NY, USA.; Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, New York, NY, USA., Li Y; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.; Yale University School of Medicine, New Haven, CT, USA., Natarajan S; VA New York Harbor Healthcare System, New York, NY, USA., Francis MO; Massachusetts Area Veterans Epidemiology Research and Information Center (MAVERIC), Boston, MA, USA., Rajeevan N; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.; Yale University School of Medicine, New Haven, CT, USA., Cheung KH; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.; Yale University School of Medicine, New Haven, CT, USA., DeLisi LE; Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA, USA., Kosten TR; Michael E. DeBakey VA Medical Center, Houston, TX, USA.; Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA., Zhao H; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.; Yale University School of Medicine, New Haven, CT, USA., Achtyes E; Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA., Buckley PF; University of Tennessee Health Science Center in Memphis, Memphis, TN, USA., Malaspina D; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lehrer D; Department of Psychiatry, Wright State University, Dayton, OH, USA., Rapaport MH; Huntsman Mental Health Institute, Department of Psychiatry, University of Utah, Salt Lake City, UT, USA., Braff DL; Department of Psychiatry, University of California, San Diego, San Diego, CA, USA.; VA San Diego Healthcare System, San Diego, CA, USA., Pato MT; Department of Psychiatry, Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Fanous AH; Department of Psychiatry, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.; Department of Psychiatry, VA Phoenix Healthcare System, Phoenix, AZ, USA., Pato CN; Department of Psychiatry, Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Huang GD; Office of Research and Development, Veterans Health Administration, Washington, DC, USA., Muralidhar S; Office of Research and Development, Veterans Health Administration, Washington, DC, USA., Gaziano JM; Massachusetts Area Veterans Epidemiology Research and Information Center (MAVERIC), Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pyarajan S; Massachusetts Area Veterans Epidemiology Research and Information Center (MAVERIC), Boston, MA, USA., Girdhar K; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lee D; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hoffman GE; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Precision Medicine and Translational Therapeutics, James J. Peters VA Medical Center, New York, NY, USA.; VISN2 Mental Illness Research, Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, New York, NY, USA., Aslan M; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT, USA.; Yale University School of Medicine, New Haven, CT, USA., Fullard JF; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Voloudakis G; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Precision Medicine and Translational Therapeutics, James J. Peters VA Medical Center, New York, NY, USA.; VISN2 Mental Illness Research, Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, New York, NY, USA., Harvey PD; Bruce W. Carter Miami Veterans Affairs (VA) Medical Center, Miami, FL, USA.; School of Medicine, University of Miami, Miami, FL, USA., Roussos P; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@va.gov.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@va.gov.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@va.gov.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@va.gov.; Center for Precision Medicine and Translational Therapeutics, James J. Peters VA Medical Center, New York, NY, USA. panagiotis.roussos@va.gov.; VISN2 Mental Illness Research, Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, New York, NY, USA. panagiotis.roussos@va.gov.
Corporate Authors: Project Among African-Americans to Explore Risks for Schizophrenia (PAARTNERS), Consortium on the Genomics of Schizophrenia (COGS), Genomic Psychiatry Cohort (GPC) Investigators, PsychAD Consortium, VA Cooperative Studies Program (CSP) #572, VA Million Veteran Program (MVP)
Source: Nature [Nature] 2026 Mar; Vol. 651 (8105), pp. 404-413. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Biological insights into schizophrenia from ancestrally diverse populations.
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  Data: <searchLink fieldCode="AU" term="%22Bigdeli+TB%22">Bigdeli TB</searchLink>; VA New York Harbor Healthcare System, New York, NY, USA. tim.bigdeli@va.gov.; Institute for Genomics in Health (IGH), SUNY Downstate Health Sciences University, New York, NY, USA. tim.bigdeli@va.gov.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, New York, NY, USA. tim.bigdeli@va.gov.; Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, New York, NY, USA. tim.bigdeli@va.gov.<br /><searchLink fieldCode="AU" term="%22Chatzinakos+C%22">Chatzinakos C</searchLink>; Institute for Genomics in Health (IGH), SUNY Downstate Health Sciences University, New York, NY, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bendl+J%22">Bendl J</searchLink>; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Barr+PB%22">Barr PB</searchLink>; VA New York Harbor Healthcare System, New York, NY, USA.; Institute for Genomics in Health (IGH), SUNY Downstate Health Sciences University, New York, NY, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, New York, NY, USA.; Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Venkatesh+S%22">Venkatesh S</searchLink>; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Precision Medicine and Translational Therapeutics, James J. 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      – TitleFull: Biological insights into schizophrenia from ancestrally diverse populations.
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            NameFull: Francis MO
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            NameFull: Rajeevan N
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            – D: 01
              M: 03
              Text: 2026 Mar
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Numbering:
            – Type: volume
              Value: 651
            – Type: issue
              Value: 8105
          Titles:
            – TitleFull: Nature
              Type: main
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