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Phase 1 study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers.

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Title: Phase 1 study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers.
Authors: Barber-Rotenberg JS; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Haas AR; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Aggarwal C; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., O'Hara M; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Hexner E; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA., Pequignot E; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Dowd E; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Ndeupen S; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Thai E; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Chen F; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Oner BS; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Czuczman C; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Gonzalez VE; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Fraietta JA; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA., Hwang WT; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA., Chew A; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Jadlowsky JK; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Marshall A; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Shea KM; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Jiang Y; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Cosey A; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Ferthio R; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Levine BL; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Plesa G; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA., Siegel DL; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Young RM; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sheppard NC; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Albelda SM; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., June CH; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tanyi JL; Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: janos.tanyi@pennmedicine.upenn.edu.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 May 06; Vol. 34 (5), pp. 2653-2665. Date of Electronic Publication: 2026 Jan 21.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase 1 study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers.
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  Data: <searchLink fieldCode="AU" term="%22Barber-Rotenberg+JS%22">Barber-Rotenberg JS</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Haas+AR%22">Haas AR</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Aggarwal+C%22">Aggarwal C</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22O'Hara+M%22">O'Hara M</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hexner+E%22">Hexner E</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pequignot+E%22">Pequignot E</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Dowd+E%22">Dowd E</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ndeupen+S%22">Ndeupen S</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Thai+E%22">Thai E</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Oner+BS%22">Oner BS</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Czuczman+C%22">Czuczman C</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+VE%22">Gonzalez VE</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Fraietta+JA%22">Fraietta JA</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hwang+WT%22">Hwang WT</searchLink>; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chew+A%22">Chew A</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Jadlowsky+JK%22">Jadlowsky JK</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Marshall+A%22">Marshall A</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Shea+KM%22">Shea KM</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cosey+A%22">Cosey A</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ferthio+R%22">Ferthio R</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Levine+BL%22">Levine BL</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Plesa+G%22">Plesa G</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Siegel+DL%22">Siegel DL</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Young+RM%22">Young RM</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sheppard+NC%22">Sheppard NC</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Albelda+SM%22">Albelda SM</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22June+CH%22">June CH</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tanyi+JL%22">Tanyi JL</searchLink>; Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: janos.tanyi@pennmedicine.upenn.edu.
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  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2026 May 06; Vol. 34 (5), pp. 2653-2665. <i>Date of Electronic Publication: </i>2026 Jan 21.
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  Data: Journal Article; Clinical Trial, Phase I
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100890581 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1525-0024 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215250016%22">15250016 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther <i>Subsets: </i>MEDLINE
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