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Silencing of human HTT by targeted CRISPR/dCas9-mediated epigenetic editing.

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Title: Silencing of human HTT by targeted CRISPR/dCas9-mediated epigenetic editing.
Authors: Tay YL; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore., Thomson SB; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada., Hnatova S; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore., Ng S; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore., Teo SR; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore., McCallum R; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada., Sim B; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore., Tarantini L; Department of Clinical Sciences and Community Health, EPIGET - Epidemiology, Epigenetics and Toxicology Laboratory, University of Milano, Milan, Italy., Tai FL; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Bollati V; Department of Clinical Sciences and Community Health, EPIGET - Epidemiology, Epigenetics and Toxicology Laboratory, University of Milano, Milan, Italy., Loh M; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Hayden MR; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada., Leavitt BR; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada., Pouladi MA; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore.; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.; Department of Medical Genetics, Djavad Mowafaghian Centre for Brain Health, Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.
Source: Journal of Huntington's disease [J Huntingtons Dis] 2026 Aug; Vol. 15 (3), pp. 399-407. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: IOS Press Country of Publication: United States NLM ID: 101589965 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-6400 (Electronic) Linking ISSN: 18796397 NLM ISO Abbreviation: J Huntingtons Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Silencing of human HTT by targeted CRISPR/dCas9-mediated epigenetic editing.
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  Data: <searchLink fieldCode="AU" term="%22Tay+YL%22">Tay YL</searchLink>; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Thomson+SB%22">Thomson SB</searchLink>; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Hnatova+S%22">Hnatova S</searchLink>; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+S%22">Ng S</searchLink>; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Teo+SR%22">Teo SR</searchLink>; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22McCallum+R%22">McCallum R</searchLink>; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Sim+B%22">Sim B</searchLink>; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tarantini+L%22">Tarantini L</searchLink>; Department of Clinical Sciences and Community Health, EPIGET - Epidemiology, Epigenetics and Toxicology Laboratory, University of Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tai+FL%22">Tai FL</searchLink>; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Bollati+V%22">Bollati V</searchLink>; Department of Clinical Sciences and Community Health, EPIGET - Epidemiology, Epigenetics and Toxicology Laboratory, University of Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Loh+M%22">Loh M</searchLink>; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Hayden+MR%22">Hayden MR</searchLink>; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Leavitt+BR%22">Leavitt BR</searchLink>; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Pouladi+MA%22">Pouladi MA</searchLink>; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Immunos, Singapore, Singapore.; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.; Department of Medical Genetics, Djavad Mowafaghian Centre for Brain Health, Edwin S. H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22IOS+Press%22">IOS Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101589965 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-6400 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218796397%22">18796397 </searchLink><i>NLM ISO Abbreviation: </i>J Huntingtons Dis <i>Subsets: </i>MEDLINE
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              Text: 2026 Aug
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              Y: 2026
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