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Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina.

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Title: Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina.
Authors: Gaire BP; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Koronyo Y; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Vit JP; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Hutton A; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Subedi L; Division of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Fuchs DT; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Swerdlow N; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Rentsendorj A; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Shahin S; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Martinon D; Division of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Robinson E; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Ljubimov AV; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Division of Applied Cell Biology and Physiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Board of Governors Regenerative Medicine Institute Eye Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Schneider JA; Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Schneider LS; Psychiatry and the Behavioral Sciences and Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Hawes D; Department of Pathology and Laboratory Medicine, Keck School of Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA., Graham SL; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia., Gupta VK; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia., Mirzaei M; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.; ProHeme Diagnostics Pty Ltd, Sydney, NSW, Australia., Black KL; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Meyer JG; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Arditi M; Division of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Crother TR; Division of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA, USA. timothy.crother@csmc.edu.; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA. timothy.crother@csmc.edu., Koronyo-Hamaoui M; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. maya.koronyo@csmc.edu.; Department of Biomedical Sciences, Division of Applied Cell Biology and Physiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. maya.koronyo@csmc.edu.; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. maya.koronyo@csmc.edu.
Source: Nature communications [Nat Commun] 2026 Jan 22; Vol. 17 (1), pp. 771. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina.
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  Data: <searchLink fieldCode="AU" term="%22Gaire+BP%22">Gaire BP</searchLink>; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Koronyo+Y%22">Koronyo Y</searchLink>; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vit+JP%22">Vit JP</searchLink>; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hutton+A%22">Hutton A</searchLink>; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Subedi+L%22">Subedi L</searchLink>; Division of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fuchs+DT%22">Fuchs DT</searchLink>; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Swerdlow+N%22">Swerdlow N</searchLink>; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rentsendorj+A%22">Rentsendorj A</searchLink>; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shahin+S%22">Shahin S</searchLink>; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Martinon+D%22">Martinon D</searchLink>; Division of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Robinson+E%22">Robinson E</searchLink>; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ljubimov+AV%22">Ljubimov AV</searchLink>; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Division of Applied Cell Biology and Physiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Board of Governors Regenerative Medicine Institute Eye Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+JA%22">Schneider JA</searchLink>; Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+LS%22">Schneider LS</searchLink>; Psychiatry and the Behavioral Sciences and Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hawes+D%22">Hawes D</searchLink>; Department of Pathology and Laboratory Medicine, Keck School of Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Graham+SL%22">Graham SL</searchLink>; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Gupta+VK%22">Gupta VK</searchLink>; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Mirzaei+M%22">Mirzaei M</searchLink>; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.; ProHeme Diagnostics Pty Ltd, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Black+KL%22">Black KL</searchLink>; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Meyer+JG%22">Meyer JG</searchLink>; Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Arditi+M%22">Arditi M</searchLink>; Division of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Crother+TR%22">Crother TR</searchLink>; Division of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA, USA. timothy.crother@csmc.edu.; Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA. timothy.crother@csmc.edu.<br /><searchLink fieldCode="AU" term="%22Koronyo-Hamaoui+M%22">Koronyo-Hamaoui M</searchLink>; Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. maya.koronyo@csmc.edu.; Department of Biomedical Sciences, Division of Applied Cell Biology and Physiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. maya.koronyo@csmc.edu.; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. maya.koronyo@csmc.edu.
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