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Streamlined resource-efficient plasma amyloid-beta mass spectrometry assay has improved biomarker performance in preclinical Alzheimer's disease.

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Title: Streamlined resource-efficient plasma amyloid-beta mass spectrometry assay has improved biomarker performance in preclinical Alzheimer's disease.
Authors: Chen Y; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Zeng X; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Olvera-Rojas M; Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada (Universidad de Granada), Granada, Spain., Sewell KR; AdventHealth Research Institute, Orlando, FL, USA.; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Perth, Western Australia, Australia., Sehrawat A; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Gu J; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Triviño-Ibañez EM; Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain.; Instituto de Investigación Biosanitaria (ibs.GRANADA), Granada, Spain., Solis-Urra P; Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada (Universidad de Granada), Granada, Spain.; AdventHealth Research Institute, Orlando, FL, USA.; Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain.; Faculty of Education and Social Sciences, Universidad Andres Bello, Viña del Mar, Chile., Gómez-Río M; Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain.; Instituto de Investigación Biosanitaria (ibs.GRANADA), Granada, Spain., Oberlin LE; AdventHealth Research Institute, Orlando, FL, USA.; Department of Psychiatry, Weill Cornell Medicine, New York, New York, USA., Kramer AF; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, Urbana, IL, USA., Hillman CH; Institute for Cognitive & Brain Health, Northeastern University, Boston, MA, USA.; Department of Psychology Northeastern University, Boston, MA, USA.; Department of Physical Therapy, Movement & Rehabilitation Sciences, Northeastern University, Boston, MA, USA., Burns JM; University of Kansas Alzheimer's Disease Research Center, Kansas City, KS, USA., Marsland AL; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA., Kang C; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., McAuley E; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, Urbana, IL, USA.; Department of Health and Kinesiology, University of Illinois Urbana-Champaign, Champaign, IL, USA., Ikonomovic MD; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Geriatric Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA., Pascoal TA; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Villemagne VL; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Lopez OL; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Cohen AD; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Esteban-Cornejo I; Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada (Universidad de Granada), Granada, Spain.; Instituto de Investigación Biosanitaria (ibs.GRANADA), Granada, Spain.; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain., Yates NA; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA., Erickson KI; AdventHealth Research Institute, Orlando, FL, USA., Karikari TK; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Karikaritk@upmc.edu.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA. Karikaritk@upmc.edu.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Karikaritk@upmc.edu.
Source: Nature communications [Nat Commun] 2026 Jan 22; Vol. 17 (1), pp. 1673. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Streamlined resource-efficient plasma amyloid-beta mass spectrometry assay has improved biomarker performance in preclinical Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zeng+X%22">Zeng X</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Olvera-Rojas+M%22">Olvera-Rojas M</searchLink>; Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada (Universidad de Granada), Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Sewell+KR%22">Sewell KR</searchLink>; AdventHealth Research Institute, Orlando, FL, USA.; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Perth, Western Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Sehrawat+A%22">Sehrawat A</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gu+J%22">Gu J</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Triviño-Ibañez+EM%22">Triviño-Ibañez EM</searchLink>; 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Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22McAuley+E%22">McAuley E</searchLink>; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, Urbana, IL, USA.; Department of Health and Kinesiology, University of Illinois Urbana-Champaign, Champaign, IL, USA.<br /><searchLink fieldCode="AU" term="%22Ikonomovic+MD%22">Ikonomovic MD</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Geriatric Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pascoal+TA%22">Pascoal TA</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Villemagne+VL%22">Villemagne VL</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lopez+OL%22">Lopez OL</searchLink>; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+AD%22">Cohen AD</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Esteban-Cornejo+I%22">Esteban-Cornejo I</searchLink>; Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada (Universidad de Granada), Granada, Spain.; Instituto de Investigación Biosanitaria (ibs.GRANADA), Granada, Spain.; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Yates+NA%22">Yates NA</searchLink>; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Erickson+KI%22">Erickson KI</searchLink>; AdventHealth Research Institute, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Karikari+TK%22">Karikari TK</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Karikaritk@upmc.edu.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA. Karikaritk@upmc.edu.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Karikaritk@upmc.edu.
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