Streamlined resource-efficient plasma amyloid-beta mass spectrometry assay has improved biomarker performance in preclinical Alzheimer's disease.
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| Title: | Streamlined resource-efficient plasma amyloid-beta mass spectrometry assay has improved biomarker performance in preclinical Alzheimer's disease. |
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| Authors: | Chen Y; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Zeng X; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Olvera-Rojas M; Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada (Universidad de Granada), Granada, Spain., Sewell KR; AdventHealth Research Institute, Orlando, FL, USA.; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Perth, Western Australia, Australia., Sehrawat A; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Gu J; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Triviño-Ibañez EM; Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain.; Instituto de Investigación Biosanitaria (ibs.GRANADA), Granada, Spain., Solis-Urra P; Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada (Universidad de Granada), Granada, Spain.; AdventHealth Research Institute, Orlando, FL, USA.; Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain.; Faculty of Education and Social Sciences, Universidad Andres Bello, Viña del Mar, Chile., Gómez-Río M; Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain.; Instituto de Investigación Biosanitaria (ibs.GRANADA), Granada, Spain., Oberlin LE; AdventHealth Research Institute, Orlando, FL, USA.; Department of Psychiatry, Weill Cornell Medicine, New York, New York, USA., Kramer AF; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, Urbana, IL, USA., Hillman CH; Institute for Cognitive & Brain Health, Northeastern University, Boston, MA, USA.; Department of Psychology Northeastern University, Boston, MA, USA.; Department of Physical Therapy, Movement & Rehabilitation Sciences, Northeastern University, Boston, MA, USA., Burns JM; University of Kansas Alzheimer's Disease Research Center, Kansas City, KS, USA., Marsland AL; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA., Kang C; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., McAuley E; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, Urbana, IL, USA.; Department of Health and Kinesiology, University of Illinois Urbana-Champaign, Champaign, IL, USA., Ikonomovic MD; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Geriatric Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA., Pascoal TA; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Villemagne VL; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Lopez OL; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Cohen AD; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Esteban-Cornejo I; Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada (Universidad de Granada), Granada, Spain.; Instituto de Investigación Biosanitaria (ibs.GRANADA), Granada, Spain.; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain., Yates NA; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA., Erickson KI; AdventHealth Research Institute, Orlando, FL, USA., Karikari TK; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Karikaritk@upmc.edu.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA. Karikaritk@upmc.edu.; Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Karikaritk@upmc.edu. |
| Source: | Nature communications [Nat Commun] 2026 Jan 22; Vol. 17 (1), pp. 1673. Date of Electronic Publication: 2026 Jan 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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