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Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants.

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Title: Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants.
Authors: Geller F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. fge@ssi.dk.; Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. fge@ssi.dk.; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. fge@ssi.dk., Wu X; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Lammi V; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Molecular and Population Genetics Program, Broad Institute, Cambridge, MA, USA., Abner E; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Valliere JT; Molecular and Population Genetics Program, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Nastou K; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Burns A; Molecular and Population Genetics Program, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Rasmussen M; Virus Research and Development Laboratory, Virus & Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark., Andersson NW; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Quinn L; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Aagaard B; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Banasik K; Department of Obstetrics and Gynecology, Copenhagen University Hospital, Amager & Hvidovre Hospital, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bliddal S; Department of Obstetrics and Gynecology, Copenhagen University Hospital, Amager & Hvidovre Hospital, Copenhagen, Denmark.; Department of Nephrology and Endocrinology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Boding L; Danish National Biobank, Statens Serum Institut, Copenhagen, Denmark., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brøns N; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Bybjerg-Grauholm J; Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Christoffersen LAN; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.; Institute of Biological Psychiatry, Copenhagen Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark., Didriksen M; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Dinh KM; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Feldt-Rasmussen U; Department of Nephrology and Endocrinology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Grønbæk K; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Biotech Research and Innovation Center (BRIC), University of Copenhagen, Copenhagen, Denmark., Kaspersen KA; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Mikkelsen C; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Novo Nordisk Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nielsen CH; Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Nielsen HS; Department of Obstetrics and Gynecology, Copenhagen University Hospital, Amager & Hvidovre Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nielsen SD; Viro-Immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Nissen J; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Sequeros CB; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Tommerup N; Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Spiliopoulos L; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Bager P; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Hviid A; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Pharmacovigilance Research Center, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sørensen E; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Pedersen OB; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lane JM; Molecular and Population Genetics Program, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Lassaunière R; Virus Research and Development Laboratory, Virus & Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark., Ollila HM; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ostrowski SR; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.; Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Corporate Authors: DBDS Genomic Consortium, Estonian Biobank Research Team, FinnGen
Source: Nature genetics [Nat Genet] 2026 Feb; Vol. 58 (2), pp. 299-306. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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