Methotrexate for Osteoarthritis: What Does the Evidence Say?

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Title: Methotrexate for Osteoarthritis: What Does the Evidence Say?
Authors: De Castro Fidalgo E Costa M; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK.; National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK., Ponchel F; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK.; National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK., Flack K; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK.; National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK., Conaghan PG; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK.; National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK., Kingsbury SR; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK. s.r.kingsbury@leeds.ac.uk.; National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK. s.r.kingsbury@leeds.ac.uk.
Source: Drugs & aging [Drugs Aging] 2026 Feb; Vol. 43 (2), pp. 123-136. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article; Review
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9102074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1969 (Electronic) Linking ISSN: 1170229X NLM ISO Abbreviation: Drugs Aging Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22De+Castro+Fidalgo+E+Costa+M%22">De Castro Fidalgo E Costa M</searchLink>; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK.; National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Ponchel+F%22">Ponchel F</searchLink>; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK.; National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Flack+K%22">Flack K</searchLink>; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK.; National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Conaghan+PG%22">Conaghan PG</searchLink>; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK.; National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Kingsbury+SR%22">Kingsbury SR</searchLink>; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK. s.r.kingsbury@leeds.ac.uk.; National Institute for Health and Care Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK. s.r.kingsbury@leeds.ac.uk.
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      – TitleFull: Methotrexate for Osteoarthritis: What Does the Evidence Say?
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              Text: 2026 Feb
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