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m-EASIX (better than EASIX) predicts severe CAR T-cell toxicities, worse overall survival, and discriminates cytokine release syndrome from sepsis.

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Title: m-EASIX (better than EASIX) predicts severe CAR T-cell toxicities, worse overall survival, and discriminates cytokine release syndrome from sepsis.
Authors: Moreno-Castaño AB; Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Centre Diagnòstic Biomèdic (CDB), Clínic Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain., Fernández S; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Medical Intensive Care Unit, Clínic Barcelona, Barcelona, Spain., Brillembourg H; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Iraola G; Medical Intensive Care Unit, Clínic Barcelona, Barcelona, Spain., Moreno DF; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Ventosa-Capell H; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Medical Intensive Care Unit, Clínic Barcelona, Barcelona, Spain., Martinez-Sanchez J; Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Centre Diagnòstic Biomèdic (CDB), Clínic Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., De Moner B; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Josep Carreras Leukaemia Research Institute (Campus Clinic), Barcelona, Spain.; Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Centre Diagnòstic Biomèdic (CDB), Clínic Barcelona, Barcelona, Spain., Molina P; Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Centre Diagnòstic Biomèdic (CDB), Clínic Barcelona, Barcelona, Spain., Ramos A; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Palomo M; Hematology External Quality Assessment Laboratory, Centre de Diagnòstic Biomèdic, Clínic Barcelona, Barcelona, Spain., Gómez-Ramírez P; Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Centre Diagnòstic Biomèdic (CDB), Clínic Barcelona, Barcelona, Spain., Ortiz-Maldonado V; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain., Martínez-Cibrián N; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain., Delgado J; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain., Oliver-Caldés A; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain., Fernández de Larrea C; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain., Salas MQ; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain., Urbano Á; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain., Téllez A; Medical Intensive Care Unit, Clínic Barcelona, Barcelona, Spain., Nicolás JM; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Medical Intensive Care Unit, Clínic Barcelona, Barcelona, Spain., Juan M; Immunology Department, Centre de Diagnòstic Biomèdic, Clínic Barcelona, Barcelona, Spain., González-Navarro A; Immunology Department, Centre de Diagnòstic Biomèdic, Clínic Barcelona, Barcelona, Spain., Penack O; Charité Hospital, Berlin, Germany., Escolar G; Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Centre Diagnòstic Biomèdic (CDB), Clínic Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain., Carreras E; Josep Carreras Leukaemia Research Institute (Campus Clinic), Barcelona, Spain., Fernández-Avilés F; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain., Castro P; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Medical Intensive Care Unit, Clínic Barcelona, Barcelona, Spain., Diaz-Ricart M; Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Centre Diagnòstic Biomèdic (CDB), Clínic Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.
Source: Frontiers in immunology [Front Immunol] 2026 Jan 07; Vol. 16, pp. 1664788. Date of Electronic Publication: 2026 Jan 07 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: m-EASIX (better than EASIX) predicts severe CAR T-cell toxicities, worse overall survival, and discriminates cytokine release syndrome from sepsis.
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  Data: <searchLink fieldCode="AU" term="%22Moreno-Castaño+AB%22">Moreno-Castaño AB</searchLink>; Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Centre Diagnòstic Biomèdic (CDB), Clínic Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández+S%22">Fernández S</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Medical Intensive Care Unit, Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Brillembourg+H%22">Brillembourg H</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Iraola+G%22">Iraola G</searchLink>; Medical Intensive Care Unit, Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Moreno+DF%22">Moreno DF</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ventosa-Capell+H%22">Ventosa-Capell H</searchLink>; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Medical Intensive Care Unit, Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez-Sanchez+J%22">Martinez-Sanchez J</searchLink>; Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Centre Diagnòstic Biomèdic (CDB), Clínic Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22De+Moner+B%22">De Moner B</searchLink>; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Josep Carreras Leukaemia Research Institute (Campus Clinic), Barcelona, Spain.; 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Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-Cibrián+N%22">Martínez-Cibrián N</searchLink>; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Delgado+J%22">Delgado J</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Oliver-Caldés+A%22">Oliver-Caldés A</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández+de+Larrea+C%22">Fernández de Larrea C</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Salas+MQ%22">Salas MQ</searchLink>; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Urbano+Á%22">Urbano Á</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Téllez+A%22">Téllez A</searchLink>; Medical Intensive Care Unit, Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Nicolás+JM%22">Nicolás JM</searchLink>; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Medical Intensive Care Unit, Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Juan+M%22">Juan M</searchLink>; Immunology Department, Centre de Diagnòstic Biomèdic, Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22González-Navarro+A%22">González-Navarro A</searchLink>; Immunology Department, Centre de Diagnòstic Biomèdic, Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Penack+O%22">Penack O</searchLink>; Charité Hospital, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Escolar+G%22">Escolar G</searchLink>; Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Centre Diagnòstic Biomèdic (CDB), Clínic Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Carreras+E%22">Carreras E</searchLink>; Josep Carreras Leukaemia Research Institute (Campus Clinic), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Avilés+F%22">Fernández-Avilés F</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Hematology Department, Institut del Càncer i Malalties de la Sang (ICAMS), IDIBAPS, Hospital Clínic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Castro+P%22">Castro P</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.; Medical Intensive Care Unit, Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Diaz-Ricart+M%22">Diaz-Ricart M</searchLink>; Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, Centre Diagnòstic Biomèdic (CDB), Clínic Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.
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