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Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway.

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Title: Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway.
Authors: Gong CC; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China., Li HK; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China., Mi YZ; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China., Chen JY; Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China., Fang ZY; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, P.R. China., Fu SL; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China., Quan L; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China., Lin B; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China., Lang JY; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China., Chen Q; Department of Endocrine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, P.R. China., Xu K; Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China., Chen MH; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.
Source: International journal of molecular medicine [Int J Mol Med] 2026 Mar; Vol. 57 (3). Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway.
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  Data: <searchLink fieldCode="AU" term="%22Gong+CC%22">Gong CC</searchLink>; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+HK%22">Li HK</searchLink>; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.<br /><searchLink fieldCode="AU" term="%22Mi+YZ%22">Mi YZ</searchLink>; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.<br /><searchLink fieldCode="AU" term="%22Chen+JY%22">Chen JY</searchLink>; Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China.<br /><searchLink fieldCode="AU" term="%22Fang+ZY%22">Fang ZY</searchLink>; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, P.R. China.<br /><searchLink fieldCode="AU" term="%22Fu+SL%22">Fu SL</searchLink>; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.<br /><searchLink fieldCode="AU" term="%22Quan+L%22">Quan L</searchLink>; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.<br /><searchLink fieldCode="AU" term="%22Lin+B%22">Lin B</searchLink>; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.<br /><searchLink fieldCode="AU" term="%22Lang+JY%22">Lang JY</searchLink>; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; Department of Endocrine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, P.R. China.<br /><searchLink fieldCode="AU" term="%22Xu+K%22">Xu K</searchLink>; Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China.<br /><searchLink fieldCode="AU" term="%22Chen+MH%22">Chen MH</searchLink>; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610032, P.R. China.
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  Data: <searchLink fieldCode="JN" term="%229810955%22">International journal of molecular medicine</searchLink> [Int J Mol Med] 2026 Mar; Vol. 57 (3). <i>Date of Electronic Publication: </i>2026 Jan 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22D%2EA%2E+Spandidos%22">D.A. Spandidos </searchLink><i>Country of Publication: </i>Greece <i>NLM ID: </i>9810955 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1791-244X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211073756%22">11073756 </searchLink><i>NLM ISO Abbreviation: </i>Int J Mol Med <i>Subsets: </i>MEDLINE
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        Value: 10.3892/ijmm.2026.5740
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              Text: 2026 Mar
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