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Peptidomimetics Inspired by α-Synuclein or Its Chaperone αB-Crystallin Differentially Modulate α-Synuclein Aggregation.

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Title: Peptidomimetics Inspired by α-Synuclein or Its Chaperone αB-Crystallin Differentially Modulate α-Synuclein Aggregation.
Authors: Bisi N; Université Paris-Saclay, CNRS, BioCIS, Bat. Henri Moissan, 17 av. des Sciences, 91400 Orsay, France., Kothuis J; Department of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy., Kaffy J; Université Paris-Saclay, CNRS, BioCIS, Bat. Henri Moissan, 17 av. des Sciences, 91400 Orsay, France., Pérez Peña H; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy.; Laboratory of Chemoinformatics, Faculty of Chemistry, Université de Strasbourg, 67081 Strasbourg, France., Schulz C; Institut für Physikalische Biologie, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Düsseldorf, 40204 Düsseldorf, Germany., De Luca CMG; Unit of Neurology 5 - Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy., Ciullini A; Unit of Laboratory Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy., Dellarole IL; Unit of Laboratory Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy., Radal L; Université Paris-Saclay, CNRS, BioCIS, Bat. Henri Moissan, 17 av. des Sciences, 91400 Orsay, France., Moda F; Unit of Laboratory Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy.; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Via Fratelli Cervi 93, Segrate, 20054 Milano, Italy.; Fondazione IRCCS Istituto Neurologico Carlo Besta, via Celoria 11, 20133 Milano, Italy., Cappelletti G; Department of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy., Horvath D; Laboratory of Chemoinformatics, Faculty of Chemistry, Université de Strasbourg, 67081 Strasbourg, France., Pieraccini S; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy., Hoyer W; Institut für Physikalische Biologie, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Düsseldorf, 40204 Düsseldorf, Germany., Halgand F; Université Paris-Saclay, CNRS, Institut de Chimie Physique, 91405 Orsay, France., Tonali N; Université Paris-Saclay, CNRS, BioCIS, Bat. Henri Moissan, 17 av. des Sciences, 91400 Orsay, France., Ongeri S; Université Paris-Saclay, CNRS, BioCIS, Bat. Henri Moissan, 17 av. des Sciences, 91400 Orsay, France.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Feb 26; Vol. 69 (4), pp. 4059-4077. Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Bisi+N%22">Bisi N</searchLink>; Université Paris-Saclay, CNRS, BioCIS, Bat. Henri Moissan, 17 av. des Sciences, 91400 Orsay, France.<br /><searchLink fieldCode="AU" term="%22Kothuis+J%22">Kothuis J</searchLink>; Department of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Kaffy+J%22">Kaffy J</searchLink>; Université Paris-Saclay, CNRS, BioCIS, Bat. Henri Moissan, 17 av. des Sciences, 91400 Orsay, France.<br /><searchLink fieldCode="AU" term="%22Pérez+Peña+H%22">Pérez Peña H</searchLink>; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy.; Laboratory of Chemoinformatics, Faculty of Chemistry, Université de Strasbourg, 67081 Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Schulz+C%22">Schulz C</searchLink>; Institut für Physikalische Biologie, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Düsseldorf, 40204 Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22De+Luca+CMG%22">De Luca CMG</searchLink>; Unit of Neurology 5 - Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Ciullini+A%22">Ciullini A</searchLink>; Unit of Laboratory Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Dellarole+IL%22">Dellarole IL</searchLink>; Unit of Laboratory Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Radal+L%22">Radal L</searchLink>; Université Paris-Saclay, CNRS, BioCIS, Bat. Henri Moissan, 17 av. des Sciences, 91400 Orsay, France.<br /><searchLink fieldCode="AU" term="%22Moda+F%22">Moda F</searchLink>; Unit of Laboratory Medicine - Laboratory of Clinical Pathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy.; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Via Fratelli Cervi 93, Segrate, 20054 Milano, Italy.; Fondazione IRCCS Istituto Neurologico Carlo Besta, via Celoria 11, 20133 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Cappelletti+G%22">Cappelletti G</searchLink>; Department of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Horvath+D%22">Horvath D</searchLink>; Laboratory of Chemoinformatics, Faculty of Chemistry, Université de Strasbourg, 67081 Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Pieraccini+S%22">Pieraccini S</searchLink>; Department of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Hoyer+W%22">Hoyer W</searchLink>; Institut für Physikalische Biologie, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Düsseldorf, 40204 Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Halgand+F%22">Halgand F</searchLink>; Université Paris-Saclay, CNRS, Institut de Chimie Physique, 91405 Orsay, France.<br /><searchLink fieldCode="AU" term="%22Tonali+N%22">Tonali N</searchLink>; Université Paris-Saclay, CNRS, BioCIS, Bat. Henri Moissan, 17 av. des Sciences, 91400 Orsay, France.<br /><searchLink fieldCode="AU" term="%22Ongeri+S%22">Ongeri S</searchLink>; Université Paris-Saclay, CNRS, BioCIS, Bat. Henri Moissan, 17 av. des Sciences, 91400 Orsay, France.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Feb 26; Vol. 69 (4), pp. 4059-4077. <i>Date of Electronic Publication: </i>2026 Jan 23.
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