IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma.

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Title: IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma.
Authors: Karakousi T; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA., Cristaldi V; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA., Lopes de Oliveira ML; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA., Delclaux I; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA., Besson NR; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA., Geraldo LH; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Neurology, NYU Grossman School of Medicine, New York, NY 10016, USA., González-Robles TJ; Institute of Systems Genetics, Department of Precision Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, NYU Grossman School of Medicine, New York, NY 10016, USA., McDonnough DR; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA., Martinez-Krams D; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA., da Silva G; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA., Breazeale AP; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, OR 97213, USA., Encarnacion-Rosado J; Department of Radiation Oncology, New York University Grossman School of Medicine, New York, NY 10016, USA., Pozniak J; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, 3000 Leuven, Belgium., Qiu S; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA., Illa Bochaca I; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA., Kaiza ME; Department of Immunology, Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15261-9950, USA., Kim HM; Department of Immunology, Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15261-9950, USA., Bruno TC; Department of Immunology, Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15261-9950, USA., Reizis B; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA., Moshiri AS; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA., Kimmelman AC; Department of Radiation Oncology, New York University Grossman School of Medicine, New York, NY 10016, USA; Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Ruggles KV; Institute of Systems Genetics, Department of Precision Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA; Division of Precision Medicine, Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA., Osman I; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA; Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA., Marine JC; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, 3000 Leuven, Belgium., Chandel NS; Feinberg School of Medicine, Northwestern University, Chicago, IL 60637, USA., Lund AW; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, OR 97213, USA; Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA. Electronic address: amanda.lund@nyulangone.org.
Source: Cancer cell [Cancer Cell] 2026 Apr 13; Vol. 44 (4), pp. 792-808.e9. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE
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  Data: IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma.
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  Data: <searchLink fieldCode="AU" term="%22Karakousi+T%22">Karakousi T</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Cristaldi+V%22">Cristaldi V</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Lopes+de+Oliveira+ML%22">Lopes de Oliveira ML</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Delclaux+I%22">Delclaux I</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Besson+NR%22">Besson NR</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Geraldo+LH%22">Geraldo LH</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Neurology, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22González-Robles+TJ%22">González-Robles TJ</searchLink>; Institute of Systems Genetics, Department of Precision Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22McDonnough+DR%22">McDonnough DR</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Martinez-Krams+D%22">Martinez-Krams D</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22da+Silva+G%22">da Silva G</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Breazeale+AP%22">Breazeale AP</searchLink>; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, OR 97213, USA.<br /><searchLink fieldCode="AU" term="%22Encarnacion-Rosado+J%22">Encarnacion-Rosado J</searchLink>; Department of Radiation Oncology, New York University Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Pozniak+J%22">Pozniak J</searchLink>; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Qiu+S%22">Qiu S</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Illa+Bochaca+I%22">Illa Bochaca I</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Kaiza+ME%22">Kaiza ME</searchLink>; Department of Immunology, Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15261-9950, USA.<br /><searchLink fieldCode="AU" term="%22Kim+HM%22">Kim HM</searchLink>; Department of Immunology, Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15261-9950, USA.<br /><searchLink fieldCode="AU" term="%22Bruno+TC%22">Bruno TC</searchLink>; Department of Immunology, Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15261-9950, USA.<br /><searchLink fieldCode="AU" term="%22Reizis+B%22">Reizis B</searchLink>; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Moshiri+AS%22">Moshiri AS</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Kimmelman+AC%22">Kimmelman AC</searchLink>; Department of Radiation Oncology, New York University Grossman School of Medicine, New York, NY 10016, USA; Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Ruggles+KV%22">Ruggles KV</searchLink>; Institute of Systems Genetics, Department of Precision Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA; Division of Precision Medicine, Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Osman+I%22">Osman I</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA; Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Marine+JC%22">Marine JC</searchLink>; Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Chandel+NS%22">Chandel NS</searchLink>; Feinberg School of Medicine, Northwestern University, Chicago, IL 60637, USA.<br /><searchLink fieldCode="AU" term="%22Lund+AW%22">Lund AW</searchLink>; Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, OR 97213, USA; Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY 10016, USA. Electronic address: amanda.lund@nyulangone.org.
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