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Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational study.

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Title: Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational study.
Authors: Park G; Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA., Khan MH; Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA., Andrushko JW; Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada; Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK., Banaj N; Department of Clinical Neuroscience and Neurorehabilitation, Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Borich MR; Rehabilitation Medicine and Physical Therapy, Emory University, Atlanta, GA, USA., Boyd LA; Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada., Brodtmann A; Cognitive Health Initiative, School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Brown TR; Department of Radiology, Medical University of South Carolina, Mount Pleasant, SC, USA., Buetefisch CM; Department of Neurology, Emory University, Atlanta, GA, USA., Conforto AB; LIM-44, Laboratory of Magnetic Resonance Imaging in Neuroradiology, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil; Hospital Israelita Albert Einstein, Sao Paulo, Brazil., Cramer SC; Department of Neurology, UCLA, Los Angeles, CA, USA; California Rehabilitation Institute, Los Angeles, CA, USA., Dimyan M; UM Rehabilitation and Orthopaedic Institute, University of Maryland, Baltimore, MD, USA., Domin M; Core Unit Functional Imaging, University Medicine Greifswald, Greifswald, Germany., Donnelly MR; Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA., Egorova-Brumley N; Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC, Australia., Ermer ER; Department of Neurology, University of Maryland, Baltimore, MD, USA., Feng W; Department of Neurology, Duke University School of Medicine, Durham, NC, USA., Geranmayeh F; Department of Brain Sciences, Imperial College London, London, UK., Hanlon CA; Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC, USA., Hordacre B; Innovation, Implementation, and Clinical Translation in Health, University of South Australia, Adelaide, SA, Australia., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Kautz SA; Department of Health Sciences and Research., Khlif MS; Cognitive Health Initiative, School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Liu J; Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China., Lotze M; Core Unit Functional Imaging, University Medicine Greifswald, Greifswald, Germany., MacIntosh BJ; Medical Biophysics, University of Toronto, Toronto, ON, Canada., Mohamed FB; Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA., Nordvik JE; CatoSenteret Rehabilitation Center, Son, Norway., Piras F; Department of Clinical Neuroscience and Neurorehabilitation, Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Revill KP; Facility for Education and Research in Neuroscience, Emory University, Atlanta, GA, USA., Robertson AD; Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada., Schranz C; Department of Rehabilitation Sciences, Medical University of South Carolina, Charleston, SC, USA., Schweighofer N; Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA., Seo NJ; Department of Health Sciences and Research; Department of Rehabilitation Sciences, Medical University of South Carolina, Charleston, SC, USA., Soekadar SR; Clinical Neurotechnology, Charité-University Medicine Berlin, Berlin, Germany., Srivastava S; Courage Kenny Rehabilitation Institute, Allina Health, Minneapolis, MN, USA., Tavenner BP; Department of Psychology, University of California, Riverside, Riverside, CA, USA., Thielman GT; Department of Physical Therapy and Neuroscience, Saint Joseph's University, Philadelphia, PA, USA., Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Vecchio D; Department of Clinical Neuroscience and Neurorehabilitation, Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Werden E; Cognitive Health Initiative, School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Westlye LT; Department of Psychology, University of Oslo, Oslo, Norway., Winstein CJ; Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA., Wittenberg GF; GRECC, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Ferris JK; Graduate Program in Rehabilitation Sciences, University of British Columbia, Vancouver, BC, Canada; Gerontology Research Centre, Simon Fraser University, Vancouver, BC, Canada., Yu C; Medical Biophysics, University of Toronto, Toronto, ON, Canada., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Liew SL; Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA; Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, USA. Electronic address: sliew@usc.edu., Kim H; Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA. Electronic address: hosung.kim@loni.usc.edu.
Source: The Lancet. Digital health [Lancet Digit Health] 2026 Jan; Vol. 8 (1), pp. 100942. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101751302 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-7500 (Electronic) Linking ISSN: 25897500 NLM ISO Abbreviation: Lancet Digit Health Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Associations between contralesional neuroplasticity and motor impairment through deep learning-derived MRI regional brain age in chronic stroke (ENIGMA): a multicohort, retrospective, observational study.
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