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Multisite Cre-lox recombination enables regulatory mechanism elucidation and systematic engineering of echinocandin B biosynthesis in Aspergillus nidulans.

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Title: Multisite Cre-lox recombination enables regulatory mechanism elucidation and systematic engineering of echinocandin B biosynthesis in Aspergillus nidulans.
Authors: Ma Y; School of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China; Science and Technology Innovation Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China., Zhang Y; School of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China; Science and Technology Innovation Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China., Zhang D; School of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China., Tang Y; School of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China., Zhang W; School of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China., Yue L; School of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China., Lou W; School of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China., Meng C; School of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China., Li Y; School of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China. Electronic address: lingl816@163.com., Chen X; School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: xlchen@jiangnan.edu.cn., Zhao F; School of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China; Science and Technology Innovation Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China. Electronic address: zhaofanglong@sdfmu.edu.cn.
Source: Metabolic engineering [Metab Eng] 2026 Apr; Vol. 95, pp. 15-27. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: Belgium NLM ID: 9815657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-7184 (Electronic) Linking ISSN: 10967176 NLM ISO Abbreviation: Metab Eng Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1096-7184
DOI:10.1016/j.ymben.2026.01.009