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6-Mercaptopurine vs Mycophenolate Mofetil in Autoimmune Hepatitis and Azathioprine Intolerance: A Multicenter Study.

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Title: 6-Mercaptopurine vs Mycophenolate Mofetil in Autoimmune Hepatitis and Azathioprine Intolerance: A Multicenter Study.
Authors: Less-Horst LJ; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany. Electronic address: l.horst@uke.de., Fierenz A; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Canhão B; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Liver Disease Unit, Internal Medicine Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal., Efe C; Department of Gastroenterology, Harran University Hospital, Şanliurfa, Turkey., Díaz-González Á; Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases Group, Valdecilla Research Institute (IDIVAL), Marqués de Valdecilla University Hospital, Santander, Spain., Hartl J; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany., Hübener S; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany., Kovats PJ; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Liberal R; Gastroenterology and Hepatology Department, Centro Hospitalar Sao Joao, Alameda Prof. Hernani Monteiro, Porto, Portugal; World Gastroenterology Organization (WGO) Porto Training Center, Porto, Portugal., Lohse AW; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany., Londoño MC; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Liver Unit, Hospital Clínic Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain., Lytvyak E; Division of Gastroenterology and Liver Unit, University of Alberta, Edmonton, Alberta, Canada., Macedo G; Gastroenterology and Hepatology Department, Centro Hospitalar Sao Joao, Alameda Prof. Hernani Monteiro, Porto, Portugal; World Gastroenterology Organization (WGO) Porto Training Center, Porto, Portugal., Madaleno J; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Liver Disease Unit, Internal Medicine Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal., Muñoz BM; Hospital Universitario Ramón y Cajal, CIBEREHD, IRYCIS, Universidad de Alcalá, Madrid, Spain., Montano-Loza AJ; Division of Gastroenterology and Liver Unit, University of Alberta, Edmonton, Alberta, Canada., Morris SM; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Liver Transplant Unit, Centre for Rare Diseases, Birmingham & Centre for Liver and Gastro Research, Institute of Immunology and Immunotherapy, Queen Elizabeth Hospital, University Hospital of Birmingham, University of Birmingham, Birmingham, United Kingdom., Pallotta DP; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Papp M; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Sebode M; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany., Trivedi PJ; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; National Institute for Health Research Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom; Liver Unit, University Hospitals Birmingham, Birmingham, United Kingdom; Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom., Oo YH; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Liver Transplant Unit, Centre for Rare Diseases, Birmingham & Centre for Liver and Gastro Research, Institute of Immunology and Immunotherapy, Queen Elizabeth Hospital, University Hospital of Birmingham, University of Birmingham, Birmingham, United Kingdom; National Institute for Health Research Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom; Liver Unit, University Hospitals Birmingham, Birmingham, United Kingdom; Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom., Schramm C; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Martin-Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: c.schramm@uke.de.
Source: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2026 Jan 23. Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: W.B. Saunders for the American Gastroenterological Association Country of Publication: United States NLM ID: 101160775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-7714 (Electronic) Linking ISSN: 15423565 NLM ISO Abbreviation: Clin Gastroenterol Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: 6-Mercaptopurine vs Mycophenolate Mofetil in Autoimmune Hepatitis and Azathioprine Intolerance: A Multicenter Study.
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  Data: <searchLink fieldCode="AU" term="%22Less-Horst+LJ%22">Less-Horst LJ</searchLink>; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany. Electronic address: l.horst@uke.de.<br /><searchLink fieldCode="AU" term="%22Fierenz+A%22">Fierenz A</searchLink>; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Canhão+B%22">Canhão B</searchLink>; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Liver Disease Unit, Internal Medicine Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Efe+C%22">Efe C</searchLink>; Department of Gastroenterology, Harran University Hospital, Şanliurfa, Turkey.<br /><searchLink fieldCode="AU" term="%22Díaz-González+Á%22">Díaz-González Á</searchLink>; Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases Group, Valdecilla Research Institute (IDIVAL), Marqués de Valdecilla University Hospital, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Hartl+J%22">Hartl J</searchLink>; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hübener+S%22">Hübener S</searchLink>; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kovats+PJ%22">Kovats PJ</searchLink>; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.<br /><searchLink fieldCode="AU" term="%22Liberal+R%22">Liberal R</searchLink>; Gastroenterology and Hepatology Department, Centro Hospitalar Sao Joao, Alameda Prof. Hernani Monteiro, Porto, Portugal; World Gastroenterology Organization (WGO) Porto Training Center, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Lohse+AW%22">Lohse AW</searchLink>; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Londoño+MC%22">Londoño MC</searchLink>; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Liver Unit, Hospital Clínic Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Lytvyak+E%22">Lytvyak E</searchLink>; Division of Gastroenterology and Liver Unit, University of Alberta, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Macedo+G%22">Macedo G</searchLink>; Gastroenterology and Hepatology Department, Centro Hospitalar Sao Joao, Alameda Prof. Hernani Monteiro, Porto, Portugal; World Gastroenterology Organization (WGO) Porto Training Center, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Madaleno+J%22">Madaleno J</searchLink>; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Liver Disease Unit, Internal Medicine Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Muñoz+BM%22">Muñoz BM</searchLink>; Hospital Universitario Ramón y Cajal, CIBEREHD, IRYCIS, Universidad de Alcalá, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Montano-Loza+AJ%22">Montano-Loza AJ</searchLink>; Division of Gastroenterology and Liver Unit, University of Alberta, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Morris+SM%22">Morris SM</searchLink>; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Liver Transplant Unit, Centre for Rare Diseases, Birmingham & Centre for Liver and Gastro Research, Institute of Immunology and Immunotherapy, Queen Elizabeth Hospital, University Hospital of Birmingham, University of Birmingham, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pallotta+DP%22">Pallotta DP</searchLink>; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Papp+M%22">Papp M</searchLink>; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.<br /><searchLink fieldCode="AU" term="%22Sebode+M%22">Sebode M</searchLink>; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Trivedi+PJ%22">Trivedi PJ</searchLink>; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; National Institute for Health Research Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom; Liver Unit, University Hospitals Birmingham, Birmingham, United Kingdom; Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Oo+YH%22">Oo YH</searchLink>; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Liver Transplant Unit, Centre for Rare Diseases, Birmingham & Centre for Liver and Gastro Research, Institute of Immunology and Immunotherapy, Queen Elizabeth Hospital, University Hospital of Birmingham, University of Birmingham, Birmingham, United Kingdom; National Institute for Health Research Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom; Liver Unit, University Hospitals Birmingham, Birmingham, United Kingdom; Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Schramm+C%22">Schramm C</searchLink>; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER), Hamburg, Germany; Martin-Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: c.schramm@uke.de.
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