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Enhanced lysosomal exocytosis and altered growth factor signaling are associated with cartilage pathology in a model of mucopolysaccharidosis type IVA.

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Title: Enhanced lysosomal exocytosis and altered growth factor signaling are associated with cartilage pathology in a model of mucopolysaccharidosis type IVA.
Authors: Lee JJ; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Lu PN; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Dukes-Rimsky L; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Jeter C; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Colonna MB; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Poplawski AB; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Arno G; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Hallman J; Biochemical Genetics Laboratory, Greenwood Genetic Center, Greenwood, SC 29646, USA., Underwood C; Biochemical Genetics Laboratory, Greenwood Genetic Center, Greenwood, SC 29646, USA., Basu A; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA., Pollard L; Biochemical Genetics Laboratory, Greenwood Genetic Center, Greenwood, SC 29646, USA., Weiss RJ; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA., Steet R; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA., Flanagan-Steet H; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.
Source: Disease models & mechanisms [Dis Model Mech] 2026 Feb 01; Vol. 19 (2). Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article
Journal Info: Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101483332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1754-8411 (Electronic) Linking ISSN: 17548403 NLM ISO Abbreviation: Dis Model Mech Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Enhanced lysosomal exocytosis and altered growth factor signaling are associated with cartilage pathology in a model of mucopolysaccharidosis type IVA.
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  Data: <searchLink fieldCode="AU" term="%22Lee+JJ%22">Lee JJ</searchLink>; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.<br /><searchLink fieldCode="AU" term="%22Lu+PN%22">Lu PN</searchLink>; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.<br /><searchLink fieldCode="AU" term="%22Dukes-Rimsky+L%22">Dukes-Rimsky L</searchLink>; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.<br /><searchLink fieldCode="AU" term="%22Jeter+C%22">Jeter C</searchLink>; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.<br /><searchLink fieldCode="AU" term="%22Colonna+MB%22">Colonna MB</searchLink>; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.<br /><searchLink fieldCode="AU" term="%22Poplawski+AB%22">Poplawski AB</searchLink>; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.<br /><searchLink fieldCode="AU" term="%22Arno+G%22">Arno G</searchLink>; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.<br /><searchLink fieldCode="AU" term="%22Hallman+J%22">Hallman J</searchLink>; Biochemical Genetics Laboratory, Greenwood Genetic Center, Greenwood, SC 29646, USA.<br /><searchLink fieldCode="AU" term="%22Underwood+C%22">Underwood C</searchLink>; Biochemical Genetics Laboratory, Greenwood Genetic Center, Greenwood, SC 29646, USA.<br /><searchLink fieldCode="AU" term="%22Basu+A%22">Basu A</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Pollard+L%22">Pollard L</searchLink>; Biochemical Genetics Laboratory, Greenwood Genetic Center, Greenwood, SC 29646, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+RJ%22">Weiss RJ</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Steet+R%22">Steet R</searchLink>; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.<br /><searchLink fieldCode="AU" term="%22Flanagan-Steet+H%22">Flanagan-Steet H</searchLink>; JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA.
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  Data: <searchLink fieldCode="JN" term="%22101483332%22">Disease models & mechanisms</searchLink> [Dis Model Mech] 2026 Feb 01; Vol. 19 (2). <i>Date of Electronic Publication: </i>2026 Mar 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Company+of+Biologists+Ltd%22">Company of Biologists Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101483332 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1754-8411 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217548403%22">17548403 </searchLink><i>NLM ISO Abbreviation: </i>Dis Model Mech <i>Subsets: </i>MEDLINE
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        Value: 10.1242/dmm.052582
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              Text: 2026 Feb 01
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