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Low hyper-oxygen exposure induces p21-dependent p53-independent senescence in alveolar cells.

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Title: Low hyper-oxygen exposure induces p21-dependent p53-independent senescence in alveolar cells.
Authors: Lee CH; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan., Lin KH; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan., Lee MS; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan., Lin CJ; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taiwan., Yang RC; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan.; Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan.; School of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan., Wang SC; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taiwan., Hsu CS; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan., Kao JK; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taiwan.; Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung city, Taiwan.
Source: International journal of medical sciences [Int J Med Sci] 2026 Jan 01; Vol. 23 (2), pp. 497-509. Date of Electronic Publication: 2026 Jan 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE
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  Data: Low hyper-oxygen exposure induces p21-dependent p53-independent senescence in alveolar cells.
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  Data: <searchLink fieldCode="AU" term="%22Lee+CH%22">Lee CH</searchLink>; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+KH%22">Lin KH</searchLink>; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+MS%22">Lee MS</searchLink>; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CJ%22">Lin CJ</searchLink>; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+RC%22">Yang RC</searchLink>; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan.; Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan.; School of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+SC%22">Wang SC</searchLink>; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+CS%22">Hsu CS</searchLink>; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kao+JK%22">Kao JK</searchLink>; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, Changhua, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taiwan.; Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung city, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101213954%22">International journal of medical sciences</searchLink> [Int J Med Sci] 2026 Jan 01; Vol. 23 (2), pp. 497-509. <i>Date of Electronic Publication: </i>2026 Jan 01 (<i>Print Publication: </i>2026).
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        Value: 10.7150/ijms.120133
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