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Oncogenic p53 induces mitotic errors in lung cancer cells by recopying DNA replication forks conferring targetable proliferation advantage.

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Title: Oncogenic p53 induces mitotic errors in lung cancer cells by recopying DNA replication forks conferring targetable proliferation advantage.
Authors: Singh S; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Cellular Molecular Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA., Gheghiani L; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Cellular Molecular Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA., Velasco B; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Cellular Molecular Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA., Frum R; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Internal Medicine, Division of Hematology, Oncology and Palliative Care, Virginia Commonwealth University, Richmond, VA, USA., Grossman SR; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Internal Medicine, Division of Hematology, Oncology and Palliative Care, Virginia Commonwealth University, Richmond, VA, USA., Windle B; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, VCU School of Dentistry, Virginia Commonwealth University, Richmond, VA, USA., Deb S; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Cellular Molecular Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA., Deb SP; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA. Swati.Deb@vcuhealth.org.; Department of Cellular Molecular Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA. Swati.Deb@vcuhealth.org.
Source: Cell death and differentiation [Cell Death Differ] 2026 Jan 26. Date of Electronic Publication: 2026 Jan 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Oncogenic p53 induces mitotic errors in lung cancer cells by recopying DNA replication forks conferring targetable proliferation advantage.
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  Data: <searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Cellular Molecular Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Gheghiani+L%22">Gheghiani L</searchLink>; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Cellular Molecular Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Velasco+B%22">Velasco B</searchLink>; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Cellular Molecular Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Frum+R%22">Frum R</searchLink>; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Internal Medicine, Division of Hematology, Oncology and Palliative Care, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Grossman+SR%22">Grossman SR</searchLink>; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Internal Medicine, Division of Hematology, Oncology and Palliative Care, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Windle+B%22">Windle B</searchLink>; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, VCU School of Dentistry, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Deb+S%22">Deb S</searchLink>; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.; Department of Cellular Molecular Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Deb+SP%22">Deb SP</searchLink>; VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA. Swati.Deb@vcuhealth.org.; Department of Cellular Molecular Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA. Swati.Deb@vcuhealth.org.
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        Value: 10.1038/s41418-026-01670-4
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        Text: English
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              Text: 2026 Jan 26
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