Phase I/II Study of the PARP Inhibitor Olaparib and Irinotecan in Children and Young Adults with Recurrent/Refractory Malignancies: Arm D of the AcSé-ESMART Trial.
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| Title: | Phase I/II Study of the PARP Inhibitor Olaparib and Irinotecan in Children and Young Adults with Recurrent/Refractory Malignancies: Arm D of the AcSé-ESMART Trial. |
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| Authors: | Gatz SA; Department of Cancer and Genomic Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom.; Department of Paediatric Oncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom., Berlanga P; Department of Pediatric and Adolescent Oncology, Gustave Roussy, Villejuif, France.; Université Paris-Saclay, Gustave Roussy, Inserm U1360, Villejuif, France., Le Teuff G; Biostatistics and Epidemiology Unit, Inserm U1018, CESP, Gustave Roussy, Université Paris-Saclay, UVSQ, Villejuif, France., Valiev I; Université Paris-Saclay, Gustave Roussy , Inserm U1361, Villejuif, France., Leruste A; Institut Curie , SIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), PSL Research University, Paris, France., André N; Department of Pediatric Oncology, AP-HM, Hôpital de la Timone, Marseille, France.; Inserm UMR 1068, CNRS UMR 7258, Aix Marseille Université U105, Cancer Research Center (CRCM), Marseille, France., Bluteau D; Université Paris-Saclay, Gustave Roussy, Inserm U1360, Villejuif, France.; EPHE, Gustave Roussy, PSL University, Villejuif, France., Corradini N; Department of Pediatric Oncology, Institut d'Hematologie et d'Oncologie Pédiatrique, Centre Léon Bérard, Lyon, France., Rubino J; Clinical Research Direction, Gustave Roussy, Villejuif, France., Thomas F; Pharmacology Department, Inserm, CRCT, Institut Universitaire du Cancer Toulouse - Oncopole, University Toulouse, Toulouse, France., Nebchi S; Biostatistics and Epidemiology Unit, Inserm U1018, CESP, Gustave Roussy, Université Paris-Saclay, UVSQ, Villejuif, France., Karamouza E; Biostatistics and Epidemiology Unit, Inserm U1018, CESP, Gustave Roussy, Université Paris-Saclay, UVSQ, Villejuif, France., Petit J; Pharmacology Department, Inserm, CRCT, Institut Universitaire du Cancer Toulouse - Oncopole, University Toulouse, Toulouse, France., Thebaud E; Department of Pediatric Oncology, Centre Hospitalier Universitaire de Nantes, Nantes, France., Rubio-San-Simón A; Department of Pediatric Oncology, Hematology and Stem Cell Transplantation, Hospital Niño Jesús, Madrid, Spain., van Eijkelenburg NKA; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Marshall LV; Paediatric and Adolescent Oncology Drug Development Unit, Royal Marsden Hospital, The Institute of Cancer Research, London, United Kingdom., Raimbault S; Department of Pediatric Oncology, Centre Oscar Lambret, Lille, France., Canete A; University Hospital La Fe, Valencia, Spain., Ducassou S; Department of Pediatric Hemato-Oncology, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France., Makin G; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.; Department of Paediatric Oncology, Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom., Casanova M; Fondazione IRCCS Istituto Nazionale dei Tumori , Milan, Italy., De Carli E; Department of Pediatric Oncology, Centre Hospitalier Universitaire d'Angers, Angers, France., Petit A; Centre de Recherche Saint-Antoine, UMR_S938, AP-HP, Hôpital Armand Trousseau, Sorbonne Université, Paris, France., Cardon M; Université Paris-Saclay, Gustave Roussy, Inserm U1360, Villejuif, France.; Bioinformatic Platform, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Lacroix L; Department of Medical Biology and Pathology, Biobank and Genomic Platform, AMMICa, Inserm US23/CNRS UMS3655, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Pierron G; Unité de Génétique Somatique, Service de Génétique, Hospital Group, Institut Curie, Paris, France., Schleiermacher G; Institut Curie , SIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), PSL Research University, Paris, France.; Inserm U1330, Translational Research in Pediatric Oncology (RTOP), Research Center, Institut Curie, PSL Research University, Paris, France., Hubank MJF; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom., Soriano Fernandez A; Laboratory of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR), UAB, Barcelona, Spain., Langenberg KPS; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Castel D; Université Paris-Saclay, Gustave Roussy, Inserm U1360, Villejuif, France., Adam-de Beaumais T; Department of Pediatric and Adolescent Oncology, Gustave Roussy, Villejuif, France., Paoletti X; Biostatistics and Epidemiology Unit, Inserm U1018, CESP, Gustave Roussy, Université Paris-Saclay, UVSQ, Villejuif, France., Lukka PB; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca (United States), Gaithersburg, Maryland., Baldry R; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca (United Kingdom), Cambridge, United Kingdom., Mortimer PGS; Oncology R&D, AstraZeneca (United Kingdom), Cambridge, United Kingdom., Nikolaev SI; Université Paris-Saclay, Gustave Roussy , Inserm U1361, Villejuif, France., Geoerger B; Department of Pediatric and Adolescent Oncology, Gustave Roussy, Villejuif, France.; Université Paris-Saclay, Gustave Roussy, Inserm U1360, Villejuif, France. |
| Source: | Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2026 Apr 01; Vol. 32 (7), pp. 1210-1223. |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II; Multicenter Study |
| Journal Info: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41591981 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Phase I/II Study of the PARP Inhibitor Olaparib and Irinotecan in Children and Young Adults with Recurrent/Refractory Malignancies: Arm D of the AcSé-ESMART Trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Gatz+SA%22">Gatz SA</searchLink>; Department of Cancer and Genomic Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom.; Department of Paediatric Oncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Berlanga+P%22">Berlanga P</searchLink>; Department of Pediatric and Adolescent Oncology, Gustave Roussy, Villejuif, France.; Université Paris-Saclay, Gustave Roussy, Inserm U1360, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Le+Teuff+G%22">Le Teuff G</searchLink>; Biostatistics and Epidemiology Unit, Inserm U1018, CESP, Gustave Roussy, Université Paris-Saclay, UVSQ, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Valiev+I%22">Valiev I</searchLink>; Université Paris-Saclay, Gustave Roussy , Inserm U1361, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Leruste+A%22">Leruste A</searchLink>; Institut Curie , SIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), PSL Research University, Paris, France.<br /><searchLink fieldCode="AU" term="%22André+N%22">André N</searchLink>; Department of Pediatric Oncology, AP-HM, Hôpital de la Timone, Marseille, France.; Inserm UMR 1068, CNRS UMR 7258, Aix Marseille Université U105, Cancer Research Center (CRCM), Marseille, France.<br /><searchLink fieldCode="AU" term="%22Bluteau+D%22">Bluteau D</searchLink>; Université Paris-Saclay, Gustave Roussy, Inserm U1360, Villejuif, France.; EPHE, Gustave Roussy, PSL University, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Corradini+N%22">Corradini N</searchLink>; Department of Pediatric Oncology, Institut d'Hematologie et d'Oncologie Pédiatrique, Centre Léon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Rubino+J%22">Rubino J</searchLink>; Clinical Research Direction, Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Thomas+F%22">Thomas F</searchLink>; Pharmacology Department, Inserm, CRCT, Institut Universitaire du Cancer Toulouse - Oncopole, University Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Nebchi+S%22">Nebchi S</searchLink>; Biostatistics and Epidemiology Unit, Inserm U1018, CESP, Gustave Roussy, Université Paris-Saclay, UVSQ, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Karamouza+E%22">Karamouza E</searchLink>; Biostatistics and Epidemiology Unit, Inserm U1018, CESP, Gustave Roussy, Université Paris-Saclay, UVSQ, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Petit+J%22">Petit J</searchLink>; Pharmacology Department, Inserm, CRCT, Institut Universitaire du Cancer Toulouse - Oncopole, University Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Thebaud+E%22">Thebaud E</searchLink>; Department of Pediatric Oncology, Centre Hospitalier Universitaire de Nantes, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Rubio-San-Simón+A%22">Rubio-San-Simón A</searchLink>; Department of Pediatric Oncology, Hematology and Stem Cell Transplantation, Hospital Niño Jesús, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22van+Eijkelenburg+NKA%22">van Eijkelenburg NKA</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Marshall+LV%22">Marshall LV</searchLink>; Paediatric and Adolescent Oncology Drug Development Unit, Royal Marsden Hospital, The Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Raimbault+S%22">Raimbault S</searchLink>; Department of Pediatric Oncology, Centre Oscar Lambret, Lille, France.<br /><searchLink fieldCode="AU" term="%22Canete+A%22">Canete A</searchLink>; University Hospital La Fe, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Ducassou+S%22">Ducassou S</searchLink>; Department of Pediatric Hemato-Oncology, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Makin+G%22">Makin G</searchLink>; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.; Department of Paediatric Oncology, Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Casanova+M%22">Casanova M</searchLink>; Fondazione IRCCS Istituto Nazionale dei Tumori , Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Carli+E%22">De Carli E</searchLink>; Department of Pediatric Oncology, Centre Hospitalier Universitaire d'Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Petit+A%22">Petit A</searchLink>; Centre de Recherche Saint-Antoine, UMR&#95;S938, AP-HP, Hôpital Armand Trousseau, Sorbonne Université, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cardon+M%22">Cardon M</searchLink>; Université Paris-Saclay, Gustave Roussy, Inserm U1360, Villejuif, France.; Bioinformatic Platform, Gustave Roussy, Université Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Lacroix+L%22">Lacroix L</searchLink>; Department of Medical Biology and Pathology, Biobank and Genomic Platform, AMMICa, Inserm US23/CNRS UMS3655, Gustave Roussy, Université Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Pierron+G%22">Pierron G</searchLink>; Unité de Génétique Somatique, Service de Génétique, Hospital Group, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Schleiermacher+G%22">Schleiermacher G</searchLink>; Institut Curie , SIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), PSL Research University, Paris, France.; Inserm U1330, Translational Research in Pediatric Oncology (RTOP), Research Center, Institut Curie, PSL Research University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hubank+MJF%22">Hubank MJF</searchLink>; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Soriano+Fernandez+A%22">Soriano Fernandez A</searchLink>; Laboratory of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR), UAB, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Langenberg+KPS%22">Langenberg KPS</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Castel+D%22">Castel D</searchLink>; Université Paris-Saclay, Gustave Roussy, Inserm U1360, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Adam-de+Beaumais+T%22">Adam-de Beaumais T</searchLink>; Department of Pediatric and Adolescent Oncology, Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Paoletti+X%22">Paoletti X</searchLink>; Biostatistics and Epidemiology Unit, Inserm U1018, CESP, Gustave Roussy, Université Paris-Saclay, UVSQ, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Lukka+PB%22">Lukka PB</searchLink>; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca (United States), Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Baldry+R%22">Baldry R</searchLink>; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca (United Kingdom), Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mortimer+PGS%22">Mortimer PGS</searchLink>; Oncology R&D, AstraZeneca (United Kingdom), Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Nikolaev+SI%22">Nikolaev SI</searchLink>; Université Paris-Saclay, Gustave Roussy , Inserm U1361, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Geoerger+B%22">Geoerger B</searchLink>; Department of Pediatric and Adolescent Oncology, Gustave Roussy, Villejuif, France.; Université Paris-Saclay, Gustave Roussy, Inserm U1360, Villejuif, France. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2026 Apr 01; Vol. 32 (7), pp. 1210-1223. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41591981 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1158/1078-0432.CCR-25-3767 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1210 Titles: – TitleFull: Phase I/II Study of the PARP Inhibitor Olaparib and Irinotecan in Children and Young Adults with Recurrent/Refractory Malignancies: Arm D of the AcSé-ESMART Trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gatz SA – PersonEntity: Name: NameFull: Berlanga P – PersonEntity: Name: NameFull: Le Teuff G – PersonEntity: Name: NameFull: Valiev I – PersonEntity: Name: NameFull: Leruste A – PersonEntity: Name: NameFull: André N – PersonEntity: Name: NameFull: Bluteau D – PersonEntity: Name: NameFull: Corradini N – PersonEntity: Name: NameFull: Rubino J – PersonEntity: Name: NameFull: Thomas F – PersonEntity: Name: NameFull: Nebchi S – PersonEntity: Name: NameFull: Karamouza E – PersonEntity: Name: NameFull: Petit J – PersonEntity: Name: NameFull: Thebaud E – PersonEntity: Name: NameFull: Rubio-San-Simón A – PersonEntity: Name: NameFull: van Eijkelenburg NKA – PersonEntity: Name: NameFull: Marshall LV – PersonEntity: Name: NameFull: Raimbault S – PersonEntity: Name: NameFull: Canete A – PersonEntity: Name: NameFull: Ducassou S – PersonEntity: Name: NameFull: Makin G – PersonEntity: Name: NameFull: Casanova M – PersonEntity: Name: NameFull: De Carli E – PersonEntity: Name: NameFull: Petit A – PersonEntity: Name: NameFull: Cardon M – PersonEntity: Name: NameFull: Lacroix L – PersonEntity: Name: NameFull: Pierron G – PersonEntity: Name: NameFull: Schleiermacher G – PersonEntity: Name: NameFull: Hubank MJF – PersonEntity: Name: NameFull: Soriano Fernandez A – PersonEntity: Name: NameFull: Langenberg KPS – PersonEntity: Name: NameFull: Castel D – PersonEntity: Name: NameFull: Adam-de Beaumais T – PersonEntity: Name: NameFull: Paoletti X – PersonEntity: Name: NameFull: Lukka PB – PersonEntity: Name: NameFull: Baldry R – PersonEntity: Name: NameFull: Mortimer PGS – PersonEntity: Name: NameFull: Nikolaev SI – PersonEntity: Name: NameFull: Geoerger B IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2026 Apr 01 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1557-3265 Numbering: – Type: volume Value: 32 – Type: issue Value: 7 Titles: – TitleFull: Clinical cancer research : an official journal of the American Association for Cancer Research Type: main |
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