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Lysophosphatidic acid-induced upregulation of exosomal miR-221-3p from corneal stromal cells promotes corneal endothelial healing.

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Title: Lysophosphatidic acid-induced upregulation of exosomal miR-221-3p from corneal stromal cells promotes corneal endothelial healing.
Authors: Chen HC; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Department of Medicine, College of Medicine Chang Gung University, Taoyuan, Taiwan. Electronic address: mr3756@cgmh.org.tw., Hsueh YJ; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City, Taiwan., Meir YJ; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Department of Biomedical Sciences, College of Medicine Chang Gung University, Taoyuan, Taiwan., Lai JY; Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan; Department of Materials Engineering, Ming Chi University of Technology, New Taipei City, Taiwan., Huang CC; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan., Lu TT; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan., Cheng CM; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan., Lin SS; Department of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Hyperbaric Oxygen Medical Research Laboratory, Bone and Joint Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan., Ma DH; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Department of Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Wu WC; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Department of Medicine, College of Medicine Chang Gung University, Taoyuan, Taiwan.
Source: Biomaterials advances [Biomater Adv] 2026 May; Vol. 182, pp. 214719. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918383886206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-9508 (Electronic) Linking ISSN: 27729508 NLM ISO Abbreviation: Biomater Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lysophosphatidic acid-induced upregulation of exosomal miR-221-3p from corneal stromal cells promotes corneal endothelial healing.
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  Data: <searchLink fieldCode="AU" term="%22Chen+HC%22">Chen HC</searchLink>; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Department of Medicine, College of Medicine Chang Gung University, Taoyuan, Taiwan. Electronic address: mr3756@cgmh.org.tw.<br /><searchLink fieldCode="AU" term="%22Hsueh+YJ%22">Hsueh YJ</searchLink>; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Meir+YJ%22">Meir YJ</searchLink>; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Department of Biomedical Sciences, College of Medicine Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+JY%22">Lai JY</searchLink>; Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan; Department of Materials Engineering, Ming Chi University of Technology, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CC%22">Huang CC</searchLink>; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+TT%22">Lu TT</searchLink>; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+CM%22">Cheng CM</searchLink>; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SS%22">Lin SS</searchLink>; Department of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Hyperbaric Oxygen Medical Research Laboratory, Bone and Joint Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ma+DH%22">Ma DH</searchLink>; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Department of Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+WC%22">Wu WC</searchLink>; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan; Department of Medicine, College of Medicine Chang Gung University, Taoyuan, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%229918383886206676%22">Biomaterials advances</searchLink> [Biomater Adv] 2026 May; Vol. 182, pp. 214719. <i>Date of Electronic Publication: </i>2026 Jan 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9918383886206676 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2772-9508 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227729508%22">27729508 </searchLink><i>NLM ISO Abbreviation: </i>Biomater Adv <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bioadv.2026.214719
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        Text: English
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              M: 05
              Text: 2026 May
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