Bempedoic acid directly binds and activates PPARα.

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Bibliographic Details
Title: Bempedoic acid directly binds and activates PPARα.
Authors: Papa C; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Rose A; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Martin HNG; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Useini A; Institute for Drug Discovery, Medical Faculty, Leipzig University, 04103 Leipzig, Germany., Geier F; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Liao L; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Rodríguez-Aguilera JR; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Valina-Allo P; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Hoffmann A; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Tvardovskiy A; Institute of Functional Epigenetics (IFE), Helmholtz Munich, 85764 Neuherberg, Germany., Zulfqar F; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Zimmerman A; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital of Leipzig, Leipzig 04103, Germany., Schicht G; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital of Leipzig, Leipzig 04103, Germany., Ott F; Rudolf-Schönheimer Institute for Biochemistry, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany; Division of Hepatology, Clinic of Oncology, Gastroenterology, Hepatology and Pneumology, University Hospital Leipzig, 04103 Leipzig, Germany., Körner C; Rudolf-Schönheimer Institute for Biochemistry, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany; Division of Hepatology, Clinic of Oncology, Gastroenterology, Hepatology and Pneumology, University Hospital Leipzig, 04103 Leipzig, Germany., Engelmann B; Helmholtz-Centre for Environmental Research-UFZ GmbH, Department for Molecular Toxicology, 04318 Leipzig, Germany., Rolle-Kampczyk U; Helmholtz-Centre for Environmental Research-UFZ GmbH, Department for Molecular Toxicology, 04318 Leipzig, Germany., von Bergen M; Helmholtz-Centre for Environmental Research-UFZ GmbH, Department for Molecular Toxicology, 04318 Leipzig, Germany; German Centre for Integrative Biodiversity Research (iDiv), Halle-Jena-Leipzig, Puschstraße 4, 04103 Leipzig, Germany; Functional Proteomics, University of Leipzig, Faculty of Life Sciences, Institute of Biochemistry, Brüderstraße 34, 04103 Leipzig, Germany., Meier M; Helmholtz Pioneer Campus, Helmholtz Munich, 85764 Neuherberg, Germany; Centre for Biotechnology and Biomedicine, University of Leipzig, 04103 Leipzig, Germany., Bartke T; Institute of Functional Epigenetics (IFE), Helmholtz Munich, 85764 Neuherberg, Germany., Seehofer D; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital of Leipzig, Leipzig 04103, Germany., Klöting N; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Matz-Soja M; Rudolf-Schönheimer Institute for Biochemistry, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany; Division of Hepatology, Clinic of Oncology, Gastroenterology, Hepatology and Pneumology, University Hospital Leipzig, 04103 Leipzig, Germany., Damm G; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital of Leipzig, Leipzig 04103, Germany., Boeckel JN; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, 04103 Leipzig, Germany., Buescher JM; Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg im Breisgau, Germany., Blüher M; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany; Clinic for Endocrinology, Nephrology, and Rheumatology, Leipzig University Medical Center, Liebigstrasse 20, 04103 Leipzig, Germany., Laufs U; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, 04103 Leipzig, Germany., Bondareva O; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Sträter N; Institute of Bioanalytical Chemistry, Centre for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, 04103 Leipzig, Germany., Künze G; Institute for Drug Discovery, Medical Faculty, Leipzig University, 04103 Leipzig, Germany; Interdisciplinary Center for Bioinformatics, Leipzig University, 04107 Leipzig, Germany; Center for Scalable Data Analytics and Artificial Intelligence, Leipzig University, 04105 Leipzig, Germany., Heiker JT; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Sheikh BN; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. Electronic address: bilal.sheikh@helmholtz-munich.de.
Source: Cell metabolism [Cell Metab] 2026 Apr 07; Vol. 38 (4), pp. 824-830.e5. Date of Electronic Publication: 2026 Jan 26.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1932-7420
DOI:10.1016/j.cmet.2025.12.018