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Bempedoic acid directly binds and activates PPARα.

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Title: Bempedoic acid directly binds and activates PPARα.
Authors: Papa C; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Rose A; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Martin HNG; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Useini A; Institute for Drug Discovery, Medical Faculty, Leipzig University, 04103 Leipzig, Germany., Geier F; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Liao L; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Rodríguez-Aguilera JR; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Valina-Allo P; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Hoffmann A; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Tvardovskiy A; Institute of Functional Epigenetics (IFE), Helmholtz Munich, 85764 Neuherberg, Germany., Zulfqar F; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Zimmerman A; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital of Leipzig, Leipzig 04103, Germany., Schicht G; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital of Leipzig, Leipzig 04103, Germany., Ott F; Rudolf-Schönheimer Institute for Biochemistry, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany; Division of Hepatology, Clinic of Oncology, Gastroenterology, Hepatology and Pneumology, University Hospital Leipzig, 04103 Leipzig, Germany., Körner C; Rudolf-Schönheimer Institute for Biochemistry, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany; Division of Hepatology, Clinic of Oncology, Gastroenterology, Hepatology and Pneumology, University Hospital Leipzig, 04103 Leipzig, Germany., Engelmann B; Helmholtz-Centre for Environmental Research-UFZ GmbH, Department for Molecular Toxicology, 04318 Leipzig, Germany., Rolle-Kampczyk U; Helmholtz-Centre for Environmental Research-UFZ GmbH, Department for Molecular Toxicology, 04318 Leipzig, Germany., von Bergen M; Helmholtz-Centre for Environmental Research-UFZ GmbH, Department for Molecular Toxicology, 04318 Leipzig, Germany; German Centre for Integrative Biodiversity Research (iDiv), Halle-Jena-Leipzig, Puschstraße 4, 04103 Leipzig, Germany; Functional Proteomics, University of Leipzig, Faculty of Life Sciences, Institute of Biochemistry, Brüderstraße 34, 04103 Leipzig, Germany., Meier M; Helmholtz Pioneer Campus, Helmholtz Munich, 85764 Neuherberg, Germany; Centre for Biotechnology and Biomedicine, University of Leipzig, 04103 Leipzig, Germany., Bartke T; Institute of Functional Epigenetics (IFE), Helmholtz Munich, 85764 Neuherberg, Germany., Seehofer D; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital of Leipzig, Leipzig 04103, Germany., Klöting N; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Matz-Soja M; Rudolf-Schönheimer Institute for Biochemistry, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany; Division of Hepatology, Clinic of Oncology, Gastroenterology, Hepatology and Pneumology, University Hospital Leipzig, 04103 Leipzig, Germany., Damm G; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital of Leipzig, Leipzig 04103, Germany., Boeckel JN; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, 04103 Leipzig, Germany., Buescher JM; Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg im Breisgau, Germany., Blüher M; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany; Clinic for Endocrinology, Nephrology, and Rheumatology, Leipzig University Medical Center, Liebigstrasse 20, 04103 Leipzig, Germany., Laufs U; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, 04103 Leipzig, Germany., Bondareva O; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Sträter N; Institute of Bioanalytical Chemistry, Centre for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, 04103 Leipzig, Germany., Künze G; Institute for Drug Discovery, Medical Faculty, Leipzig University, 04103 Leipzig, Germany; Interdisciplinary Center for Bioinformatics, Leipzig University, 04107 Leipzig, Germany; Center for Scalable Data Analytics and Artificial Intelligence, Leipzig University, 04105 Leipzig, Germany., Heiker JT; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany., Sheikh BN; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. Electronic address: bilal.sheikh@helmholtz-munich.de.
Source: Cell metabolism [Cell Metab] 2026 Apr 07; Vol. 38 (4), pp. 824-830.e5. Date of Electronic Publication: 2026 Jan 26.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Bempedoic acid directly binds and activates PPARα.
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  Data: <searchLink fieldCode="AU" term="%22Papa+C%22">Papa C</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Rose+A%22">Rose A</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Martin+HNG%22">Martin HNG</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Useini+A%22">Useini A</searchLink>; Institute for Drug Discovery, Medical Faculty, Leipzig University, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Geier+F%22">Geier F</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Liao+L%22">Liao L</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Aguilera+JR%22">Rodríguez-Aguilera JR</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Valina-Allo+P%22">Valina-Allo P</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+A%22">Hoffmann A</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Tvardovskiy+A%22">Tvardovskiy A</searchLink>; Institute of Functional Epigenetics (IFE), Helmholtz Munich, 85764 Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zulfqar+F%22">Zulfqar F</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Zimmerman+A%22">Zimmerman A</searchLink>; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital of Leipzig, Leipzig 04103, Germany.<br /><searchLink fieldCode="AU" term="%22Schicht+G%22">Schicht G</searchLink>; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital of Leipzig, Leipzig 04103, Germany.<br /><searchLink fieldCode="AU" term="%22Ott+F%22">Ott F</searchLink>; Rudolf-Schönheimer Institute for Biochemistry, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany; Division of Hepatology, Clinic of Oncology, Gastroenterology, Hepatology and Pneumology, University Hospital Leipzig, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Körner+C%22">Körner C</searchLink>; Rudolf-Schönheimer Institute for Biochemistry, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany; Division of Hepatology, Clinic of Oncology, Gastroenterology, Hepatology and Pneumology, University Hospital Leipzig, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Engelmann+B%22">Engelmann B</searchLink>; Helmholtz-Centre for Environmental Research-UFZ GmbH, Department for Molecular Toxicology, 04318 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Rolle-Kampczyk+U%22">Rolle-Kampczyk U</searchLink>; Helmholtz-Centre for Environmental Research-UFZ GmbH, Department for Molecular Toxicology, 04318 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22von+Bergen+M%22">von Bergen M</searchLink>; Helmholtz-Centre for Environmental Research-UFZ GmbH, Department for Molecular Toxicology, 04318 Leipzig, Germany; German Centre for Integrative Biodiversity Research (iDiv), Halle-Jena-Leipzig, Puschstraße 4, 04103 Leipzig, Germany; Functional Proteomics, University of Leipzig, Faculty of Life Sciences, Institute of Biochemistry, Brüderstraße 34, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Meier+M%22">Meier M</searchLink>; Helmholtz Pioneer Campus, Helmholtz Munich, 85764 Neuherberg, Germany; Centre for Biotechnology and Biomedicine, University of Leipzig, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Bartke+T%22">Bartke T</searchLink>; Institute of Functional Epigenetics (IFE), Helmholtz Munich, 85764 Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Seehofer+D%22">Seehofer D</searchLink>; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital of Leipzig, Leipzig 04103, Germany.<br /><searchLink fieldCode="AU" term="%22Klöting+N%22">Klöting N</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Matz-Soja+M%22">Matz-Soja M</searchLink>; Rudolf-Schönheimer Institute for Biochemistry, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany; Division of Hepatology, Clinic of Oncology, Gastroenterology, Hepatology and Pneumology, University Hospital Leipzig, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Damm+G%22">Damm G</searchLink>; Department of Hepatobiliary Surgery and Visceral Transplantation, University Hospital of Leipzig, Leipzig 04103, Germany.<br /><searchLink fieldCode="AU" term="%22Boeckel+JN%22">Boeckel JN</searchLink>; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Buescher+JM%22">Buescher JM</searchLink>; Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg im Breisgau, Germany.<br /><searchLink fieldCode="AU" term="%22Blüher+M%22">Blüher M</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany; Clinic for Endocrinology, Nephrology, and Rheumatology, Leipzig University Medical Center, Liebigstrasse 20, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Laufs+U%22">Laufs U</searchLink>; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Bondareva+O%22">Bondareva O</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Sträter+N%22">Sträter N</searchLink>; Institute of Bioanalytical Chemistry, Centre for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Künze+G%22">Künze G</searchLink>; Institute for Drug Discovery, Medical Faculty, Leipzig University, 04103 Leipzig, Germany; Interdisciplinary Center for Bioinformatics, Leipzig University, 04107 Leipzig, Germany; Center for Scalable Data Analytics and Artificial Intelligence, Leipzig University, 04105 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Heiker+JT%22">Heiker JT</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Sheikh+BN%22">Sheikh BN</searchLink>; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Center Munich, 04103 Leipzig, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. Electronic address: bilal.sheikh@helmholtz-munich.de.
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