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Arsenite sensitizes to ferroptosis by disrupting selenium metabolism and reducing GPx4 expression.

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Title: Arsenite sensitizes to ferroptosis by disrupting selenium metabolism and reducing GPx4 expression.
Authors: Takashima H; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan., Makino R; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan., Taguchi H; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan; Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan; Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellow, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan., Ito J; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg 1-85764, Germany; Laboratory of Food Function Analysis, Graduate School of Agricultural Science, Tohoku University, Aramakiazaaoba 468-1 Aoba-ku, Sendai 980-8572, Japan., Mishima E; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg 1-85764, Germany; Department of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Japan., Takenaka Y; Laboratory of Oncology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan., Akiyama Y; Laboratory of Oncology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan., Sumi D; Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan., Conrad M; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg 1-85764, Germany; Translational Redox Biology, Natural School of Sciences, Technical University of Munich, Garching 85748, Germany., Tomikoka Y; Laboratory of Oncology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan., Toyama T; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan. Electronic address: takashi.toyama.c6@tohoku.ac.jp., Saito Y; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan. Electronic address: yoshiro.saito.a8@tohoku.ac.jp.
Source: Toxicology [Toxicology] 2026 May; Vol. 522, pp. 154409. Date of Electronic Publication: 2026 Jan 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185 (Electronic) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Arsenite sensitizes to ferroptosis by disrupting selenium metabolism and reducing GPx4 expression.
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  Data: <searchLink fieldCode="AU" term="%22Takashima+H%22">Takashima H</searchLink>; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Makino+R%22">Makino R</searchLink>; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Taguchi+H%22">Taguchi H</searchLink>; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan; Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan; Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellow, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+J%22">Ito J</searchLink>; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg 1-85764, Germany; Laboratory of Food Function Analysis, Graduate School of Agricultural Science, Tohoku University, Aramakiazaaoba 468-1 Aoba-ku, Sendai 980-8572, Japan.<br /><searchLink fieldCode="AU" term="%22Mishima+E%22">Mishima E</searchLink>; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg 1-85764, Germany; Department of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Takenaka+Y%22">Takenaka Y</searchLink>; Laboratory of Oncology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Akiyama+Y%22">Akiyama Y</searchLink>; Laboratory of Oncology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Sumi+D%22">Sumi D</searchLink>; Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.<br /><searchLink fieldCode="AU" term="%22Conrad+M%22">Conrad M</searchLink>; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg 1-85764, Germany; Translational Redox Biology, Natural School of Sciences, Technical University of Munich, Garching 85748, Germany.<br /><searchLink fieldCode="AU" term="%22Tomikoka+Y%22">Tomikoka Y</searchLink>; Laboratory of Oncology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.<br /><searchLink fieldCode="AU" term="%22Toyama+T%22">Toyama T</searchLink>; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan. Electronic address: takashi.toyama.c6@tohoku.ac.jp.<br /><searchLink fieldCode="AU" term="%22Saito+Y%22">Saito Y</searchLink>; Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan. Electronic address: yoshiro.saito.a8@tohoku.ac.jp.
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