Biomarkers of response to neoadjuvant palbociclib plus anastrozole in endocrine-resistant estrogen receptor-positive/HER2-negative breast cancer: a phase 2 trial.
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| Title: | Biomarkers of response to neoadjuvant palbociclib plus anastrozole in endocrine-resistant estrogen receptor-positive/HER2-negative breast cancer: a phase 2 trial. |
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| Authors: | Kong T; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Cancer Biology Graduate Program, Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, Department of Medicine, St. Louis, MO, USA.; Divison of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Mabry A; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Cancer Biology Graduate Program, Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, Department of Medicine, St. Louis, MO, USA., Highkin M; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Wang AZ; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Hoog J; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Guo Z; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Gonzales-Gonzales A; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Thomas S; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Song Y; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Gao F; Division of Public Health Science, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA., Opyrchal M; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Peterson L; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Ademuyiwa F; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Margenthaler J; Section of Endocrine and Oncologic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA., Aft R; Section of Endocrine and Oncologic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA., Glover-Collins K; Section of Endocrine and Oncologic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA., Nehring L; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Tao Y; Division of Public Health Science, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA., Sanati S; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Hagemann IS; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Boulos F; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Holt M; Baylor College of Medicine, Houston, TX, USA., Ding L; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Zhu W; Department of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA., Oh ST; Divison of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Bursky Center for Human Immunology & Immunotherapy, Washington University School of Medicine, St. Louis, MO, USA., Wang J; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Witkiewicz AK; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Knudsen ES; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Bose R; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Weber JD; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Goetz M; Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA., Northfelt D; Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ, USA., Luo J; Division of Public Health Science, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA. jingqinluo@wustl.edu., Ma CX; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. cynthiaxma@wustl.edu. |
| Source: | Nature communications [Nat Commun] 2026 Jan 27; Vol. 17 (1), pp. 949. Date of Electronic Publication: 2026 Jan 27. |
| Publication Type: | Journal Article; Clinical Trial, Phase II |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41593097 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Biomarkers of response to neoadjuvant palbociclib plus anastrozole in endocrine-resistant estrogen receptor-positive/HER2-negative breast cancer: a phase 2 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kong+T%22">Kong T</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Cancer Biology Graduate Program, Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, Department of Medicine, St. Louis, MO, USA.; Divison of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mabry+A%22">Mabry A</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Cancer Biology Graduate Program, Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, Department of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Highkin+M%22">Highkin M</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Wang+AZ%22">Wang AZ</searchLink>; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hoog+J%22">Hoog J</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Guo+Z%22">Guo Z</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Gonzales-Gonzales+A%22">Gonzales-Gonzales A</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+S%22">Thomas S</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Gao+F%22">Gao F</searchLink>; Division of Public Health Science, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Opyrchal+M%22">Opyrchal M</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Peterson+L%22">Peterson L</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Ademuyiwa+F%22">Ademuyiwa F</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Margenthaler+J%22">Margenthaler J</searchLink>; Section of Endocrine and Oncologic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Aft+R%22">Aft R</searchLink>; Section of Endocrine and Oncologic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Glover-Collins+K%22">Glover-Collins K</searchLink>; Section of Endocrine and Oncologic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Nehring+L%22">Nehring L</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Tao+Y%22">Tao Y</searchLink>; Division of Public Health Science, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Sanati+S%22">Sanati S</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Hagemann+IS%22">Hagemann IS</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Boulos+F%22">Boulos F</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Holt+M%22">Holt M</searchLink>; Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ding+L%22">Ding L</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+W%22">Zhu W</searchLink>; Department of Biochemistry and Molecular Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Oh+ST%22">Oh ST</searchLink>; Divison of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Bursky Center for Human Immunology & Immunotherapy, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Witkiewicz+AK%22">Witkiewicz AK</searchLink>; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Knudsen+ES%22">Knudsen ES</searchLink>; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bose+R%22">Bose R</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Weber+JD%22">Weber JD</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Goetz+M%22">Goetz M</searchLink>; Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Northfelt+D%22">Northfelt D</searchLink>; Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Luo+J%22">Luo J</searchLink>; Division of Public Health Science, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA. jingqinluo@wustl.edu.<br /><searchLink fieldCode="AU" term="%22Ma+CX%22">Ma CX</searchLink>; Divison of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. cynthiaxma@wustl.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jan 27; Vol. 17 (1), pp. 949. <i>Date of Electronic Publication: </i>2026 Jan 27. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase II – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41593097 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-026-68570-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 949 Titles: – TitleFull: Biomarkers of response to neoadjuvant palbociclib plus anastrozole in endocrine-resistant estrogen receptor-positive/HER2-negative breast cancer: a phase 2 trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kong T – PersonEntity: Name: NameFull: Mabry A – PersonEntity: Name: NameFull: Highkin M – PersonEntity: Name: NameFull: Wang AZ – PersonEntity: Name: NameFull: Hoog J – PersonEntity: Name: NameFull: Guo Z – PersonEntity: Name: NameFull: Gonzales-Gonzales A – PersonEntity: Name: NameFull: Thomas S – PersonEntity: Name: NameFull: Song Y – PersonEntity: Name: NameFull: Gao F – PersonEntity: Name: NameFull: Opyrchal M – PersonEntity: Name: NameFull: Peterson L – PersonEntity: Name: NameFull: Ademuyiwa F – PersonEntity: Name: NameFull: Margenthaler J – PersonEntity: Name: NameFull: Aft R – PersonEntity: Name: NameFull: Glover-Collins K – PersonEntity: Name: NameFull: Nehring L – PersonEntity: Name: NameFull: Tao Y – PersonEntity: Name: NameFull: Sanati S – PersonEntity: Name: NameFull: Hagemann IS – PersonEntity: Name: NameFull: Boulos F – PersonEntity: Name: NameFull: Holt M – PersonEntity: Name: NameFull: Ding L – PersonEntity: Name: NameFull: Zhu W – PersonEntity: Name: NameFull: Oh ST – PersonEntity: Name: NameFull: Wang J – PersonEntity: Name: NameFull: Witkiewicz AK – PersonEntity: Name: NameFull: Knudsen ES – PersonEntity: Name: NameFull: Bose R – PersonEntity: Name: NameFull: Weber JD – PersonEntity: Name: NameFull: Goetz M – PersonEntity: Name: NameFull: Northfelt D – PersonEntity: Name: NameFull: Luo J – PersonEntity: Name: NameFull: Ma CX IsPartOfRelationships: – BibEntity: Dates: – D: 27 M: 01 Text: 2026 Jan 27 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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