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Sec61β maintains cytoplasmic proteostasis via ARIH1-mediated translational repression upon ER stress.

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Title: Sec61β maintains cytoplasmic proteostasis via ARIH1-mediated translational repression upon ER stress.
Authors: Kadowaki H; Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. kadowaki@med.miyazaki-u.ac.jp., Hatta T; Robotic Biology Institute Inc., 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Sugiyama K; Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan., Fukaya T; Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan., Fujisawa T; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan., Hamano T; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, 252-5258, Japan., Murao N; Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan., Takami Y; Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan., Mitoma S; Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan., Natsume T; Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, 2-3-26 Aomi, Koto-ku, Tokyo, 135-0064, Japan., Sato K; Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan., Hirata H; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, 252-5258, Japan., Uechi T; Laboratory of Medical Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan., Nishitoh H; Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. nishitoh@med.miyazaki-u.ac.jp.; Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. nishitoh@med.miyazaki-u.ac.jp.
Source: EMBO reports [EMBO Rep] 2026 Feb; Vol. 27 (4), pp. 1057-1091. Date of Electronic Publication: 2026 Jan 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: Sec61β maintains cytoplasmic proteostasis via ARIH1-mediated translational repression upon ER stress.
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  Data: <searchLink fieldCode="AU" term="%22Kadowaki+H%22">Kadowaki H</searchLink>; Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. kadowaki@med.miyazaki-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Hatta+T%22">Hatta T</searchLink>; Robotic Biology Institute Inc., 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Sugiyama+K%22">Sugiyama K</searchLink>; Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.<br /><searchLink fieldCode="AU" term="%22Fukaya+T%22">Fukaya T</searchLink>; Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.<br /><searchLink fieldCode="AU" term="%22Fujisawa+T%22">Fujisawa T</searchLink>; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.<br /><searchLink fieldCode="AU" term="%22Hamano+T%22">Hamano T</searchLink>; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, 252-5258, Japan.<br /><searchLink fieldCode="AU" term="%22Murao+N%22">Murao N</searchLink>; Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.<br /><searchLink fieldCode="AU" term="%22Takami+Y%22">Takami Y</searchLink>; Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.<br /><searchLink fieldCode="AU" term="%22Mitoma+S%22">Mitoma S</searchLink>; Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.<br /><searchLink fieldCode="AU" term="%22Natsume+T%22">Natsume T</searchLink>; Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, 2-3-26 Aomi, Koto-ku, Tokyo, 135-0064, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+K%22">Sato K</searchLink>; Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.<br /><searchLink fieldCode="AU" term="%22Hirata+H%22">Hirata H</searchLink>; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, 252-5258, Japan.<br /><searchLink fieldCode="AU" term="%22Uechi+T%22">Uechi T</searchLink>; Laboratory of Medical Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.<br /><searchLink fieldCode="AU" term="%22Nishitoh+H%22">Nishitoh H</searchLink>; Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. nishitoh@med.miyazaki-u.ac.jp.; Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. nishitoh@med.miyazaki-u.ac.jp.
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