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Genetics and environment distinctively shape the human immune cell epigenome.

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Title: Genetics and environment distinctively shape the human immune cell epigenome.
Authors: Wang W; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Hariharan M; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Ding W; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Bartlett A; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Barragan C; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Castanon R; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Wang R; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.; Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, USA., Rothenberg V; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Song H; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Nery JR; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Aldridge A; Duke University School of Medicine, Bryan Research Building, Durham, NC, USA., Altshul J; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Kenworthy M; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Liu H; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Tian W; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Zhou J; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Zeng Q; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Chen H; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Wei B; Department of Genetics, Stanford University, Stanford, CA, USA., Gündüz IB; Integrative Cellular Biology & Bioinformatics Lab, Saarland University, Saarbrücken, Germany., Norell T; Healthspan, Resilience, and Performance, Florida Institute for Human and Machine Cognition, Pensacola, FL, USA., Broderick TJ; Healthspan, Resilience, and Performance, Florida Institute for Human and Machine Cognition, Pensacola, FL, USA., McClain MT; Center for Infectious Disease Diagnostics and Innovation, Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.; Durham Veterans Affairs Medical Center, Durham, NC, USA., Satterwhite LL; Department of Civil and Environmental Engineering, Pratt School of Engineering, Duke University, Durham, NC, USA., Burke TW; Center for Infectious Disease Diagnostics and Innovation, Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA., Petzold EA; Center for Infectious Disease Diagnostics and Innovation, Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA., Shen X; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA., Woods CW; Center for Infectious Disease Diagnostics and Innovation, Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.; Durham Veterans Affairs Medical Center, Durham, NC, USA., Fowler VG Jr; Center for Infectious Disease Diagnostics and Innovation, Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.; Duke Clinical Research Institute, Durham, NC, USA., Ruffin F; Center for Infectious Disease Diagnostics and Innovation, Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA., Panuwet P; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Barr DB; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Beare JL; Battelle Memorial Institute, Columbus, OH, USA., Smith AK; Battelle Memorial Institute, Columbus, OH, USA., Spurbeck RR; Battelle Memorial Institute, Columbus, OH, USA., Vangeti S; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Ramos I; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Nudelman G; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Sealfon SC; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Castellino F; U.S. Department of Health and Human Services, Administration for Strategic Preparedness and Response, Biomedical Advanced Research and Development Authority, Washington, DC, USA., Walley AM; Barinthus Biotherapeutics, Germantown, MD, USA., Evans T; Barinthus Biotherapeutics, Germantown, MD, USA., Müller F; Integrative Cellular Biology & Bioinformatics Lab, Saarland University, Saarbrücken, Germany., Greenleaf WJ; Department of Genetics, Stanford University, Stanford, CA, USA., Ecker JR; Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA. ecker@salk.edu.; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA, USA. ecker@salk.edu.
Source: Nature genetics [Nat Genet] 2026 Feb; Vol. 58 (2), pp. 392-403. Date of Electronic Publication: 2026 Jan 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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