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Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues.

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Title: Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues.
Authors: Bocher O; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. ozvan.bocher@univ-brest.fr.; Univ Brest, Inserm, EFS, UMR 1078, GGB, Brest, France. ozvan.bocher@univ-brest.fr., Arruda AL; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Technical University of Munich (TUM), School of Medicine and Health, Graduate School of Experimental Medicine, Munich, Germany.; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, UK., Yoshiji S; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; McGill Genome Centre, McGill University, Montreal, Quebec, Canada., Zhao C; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA., Huerta-Chagoya A; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Su CY; McGill Genome Centre, McGill University, Montreal, Quebec, Canada.; Canada Excellence Research Chair in Genomic Medicine, McGill University, Montréal, Québec, Canada.; Quantitative Life Sciences, McGill University, Montreal, Québec, Canada., Yin X; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Cammann D; Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Las Vegas, NV, USA., Taylor HJ; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Chen J; Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Las Vegas, NV, USA., Suzuki K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Mandla R; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Yang TY; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Mercader JM; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Flannick J; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA., Meigs JB; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Wood AC; USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA., Vujkovic M; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Voight BF; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Spracklen CN; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. eleftheria.zeggini@helmholtz-munich.de.; Technical University of Munich (TUM), TUM University Hospital, TUM School of Medicine and Health, Munich, Germany. eleftheria.zeggini@helmholtz-munich.de.
Source: Nature metabolism [Nat Metab] 2026 Feb; Vol. 8 (2), pp. 506-520. Date of Electronic Publication: 2026 Jan 27.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues.
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  Data: <searchLink fieldCode="AU" term="%22Bocher+O%22">Bocher O</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. ozvan.bocher@univ-brest.fr.; Univ Brest, Inserm, EFS, UMR 1078, GGB, Brest, France. ozvan.bocher@univ-brest.fr.<br /><searchLink fieldCode="AU" term="%22Arruda+AL%22">Arruda AL</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Technical University of Munich (TUM), School of Medicine and Health, Graduate School of Experimental Medicine, Munich, Germany.; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Yoshiji+S%22">Yoshiji S</searchLink>; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.; McGill Genome Centre, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Zhao+C%22">Zhao C</searchLink>; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.<br /><searchLink fieldCode="AU" term="%22Huerta-Chagoya+A%22">Huerta-Chagoya A</searchLink>; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Su+CY%22">Su CY</searchLink>; McGill Genome Centre, McGill University, Montreal, Quebec, Canada.; Canada Excellence Research Chair in Genomic Medicine, McGill University, Montréal, Québec, Canada.; Quantitative Life Sciences, McGill University, Montreal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Yin+X%22">Yin X</searchLink>; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Cammann+D%22">Cammann D</searchLink>; Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Las Vegas, NV, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+HJ%22">Taylor HJ</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Las Vegas, NV, USA.<br /><searchLink fieldCode="AU" term="%22Suzuki+K%22">Suzuki K</searchLink>; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Mandla+R%22">Mandla R</searchLink>; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+TY%22">Yang TY</searchLink>; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuda+F%22">Matsuda F</searchLink>; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Mercader+JM%22">Mercader JM</searchLink>; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Flannick+J%22">Flannick J</searchLink>; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Meigs+JB%22">Meigs JB</searchLink>; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wood+AC%22">Wood AC</searchLink>; USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Vujkovic+M%22">Vujkovic M</searchLink>; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Voight+BF%22">Voight BF</searchLink>; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Spracklen+CN%22">Spracklen CN</searchLink>; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rotter+JI%22">Rotter JI</searchLink>; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.<br /><searchLink fieldCode="AU" term="%22Morris+AP%22">Morris AP</searchLink>; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Zeggini+E%22">Zeggini E</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. eleftheria.zeggini@helmholtz-munich.de.; Technical University of Munich (TUM), TUM University Hospital, TUM School of Medicine and Health, Munich, Germany. eleftheria.zeggini@helmholtz-munich.de.
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