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Biopsy RNA-seq captures TROP-2-linked migration and clonal resistance to forecast aggressiveness in metastatic melanoma.

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Title: Biopsy RNA-seq captures TROP-2-linked migration and clonal resistance to forecast aggressiveness in metastatic melanoma.
Authors: Betti M; Biostatistics, Bioinformatics and Clinical Trial Center, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.; Department of Computer, Control and Management Engineering (DIAG), Sapienza University of Rome, Rome, Italy., Accetta C; Department of Pathology Unit, IRCSS-Regina Elena National Cancer Institute, Rome, 00144, Italy.; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy., Arteni BAM; Department of Pathology Unit, IRCSS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Rosselli A; Biostatistics, Bioinformatics and Clinical Trial Center, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Melucci E; Department of Pathology Unit, IRCSS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Visca P; Department of Pathology Unit, IRCSS-Regina Elena National Cancer Institute, Rome, 00144, Italy. paolo.visca@ifo.it., Botti C; Department of Surgery, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Pelle F; Department of Surgery, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Russillo M; Sarcoma and Rare Tumors Departmental Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Ferraresi V; Sarcoma and Rare Tumors Departmental Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Migliano E; UOSD Plastic and Regenerative Surgery, San Gallicano Dermatological Institute IRCCS, Rome, 00144, Italy., Cerro M; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, 00185, Italy., Scalera S; Biostatistics, Bioinformatics and Clinical Trial Center, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy., De Nicola F; Gene Expression and Cancer Models Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Matteoni S; Translational Oncology Research Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Covino D; Translational Oncology Research Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Guerrisi A; Radiology and Diagnostic Imaging Unit, Department of Clinical and Dermatological Research, San Gallicano Dermatological Institute IRCCS, Rome, 00144, Italy., Pallocca M; Istituto degli Endotipi in Oncologia, Metabolismo e Immunologia National Research Council, Naples, 80131, Italy., Fanciulli M; Gene Expression and Cancer Models Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Pescarmona E; Department of Pathology Unit, IRCSS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Blandino G; Translational Oncology Research Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Mancini R; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, 00161, Italy., Falcone I; Gene Expression and Cancer Models Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy., Di Martino S; Department of Pathology Unit, IRCSS-Regina Elena National Cancer Institute, Rome, 00144, Italy. simona.dimartino@ifo.it.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 Jan 28; Vol. 45 (1). Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Biopsy RNA-seq captures TROP-2-linked migration and clonal resistance to forecast aggressiveness in metastatic melanoma.
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  Data: <searchLink fieldCode="AU" term="%22Betti+M%22">Betti M</searchLink>; Biostatistics, Bioinformatics and Clinical Trial Center, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.; Department of Computer, Control and Management Engineering (DIAG), Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Accetta+C%22">Accetta C</searchLink>; Department of Pathology Unit, IRCSS-Regina Elena National Cancer Institute, Rome, 00144, Italy.; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Arteni+BAM%22">Arteni BAM</searchLink>; Department of Pathology Unit, IRCSS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Rosselli+A%22">Rosselli A</searchLink>; Biostatistics, Bioinformatics and Clinical Trial Center, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Melucci+E%22">Melucci E</searchLink>; Department of Pathology Unit, IRCSS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Visca+P%22">Visca P</searchLink>; Department of Pathology Unit, IRCSS-Regina Elena National Cancer Institute, Rome, 00144, Italy. paolo.visca@ifo.it.<br /><searchLink fieldCode="AU" term="%22Botti+C%22">Botti C</searchLink>; Department of Surgery, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Pelle+F%22">Pelle F</searchLink>; Department of Surgery, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Russillo+M%22">Russillo M</searchLink>; Sarcoma and Rare Tumors Departmental Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Ferraresi+V%22">Ferraresi V</searchLink>; Sarcoma and Rare Tumors Departmental Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Migliano+E%22">Migliano E</searchLink>; UOSD Plastic and Regenerative Surgery, San Gallicano Dermatological Institute IRCCS, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Cerro+M%22">Cerro M</searchLink>; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, 00185, Italy.<br /><searchLink fieldCode="AU" term="%22Scalera+S%22">Scalera S</searchLink>; Biostatistics, Bioinformatics and Clinical Trial Center, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22De+Nicola+F%22">De Nicola F</searchLink>; Gene Expression and Cancer Models Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Matteoni+S%22">Matteoni S</searchLink>; Translational Oncology Research Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Covino+D%22">Covino D</searchLink>; Translational Oncology Research Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Guerrisi+A%22">Guerrisi A</searchLink>; Radiology and Diagnostic Imaging Unit, Department of Clinical and Dermatological Research, San Gallicano Dermatological Institute IRCCS, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Pallocca+M%22">Pallocca M</searchLink>; Istituto degli Endotipi in Oncologia, Metabolismo e Immunologia National Research Council, Naples, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Fanciulli+M%22">Fanciulli M</searchLink>; Gene Expression and Cancer Models Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Pescarmona+E%22">Pescarmona E</searchLink>; Department of Pathology Unit, IRCSS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Blandino+G%22">Blandino G</searchLink>; Translational Oncology Research Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Mancini+R%22">Mancini R</searchLink>; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, 00161, Italy.<br /><searchLink fieldCode="AU" term="%22Falcone+I%22">Falcone I</searchLink>; Gene Expression and Cancer Models Unit, IRCCS-Regina Elena National Cancer Institute, Rome, 00144, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Martino+S%22">Di Martino S</searchLink>; Department of Pathology Unit, IRCSS-Regina Elena National Cancer Institute, Rome, 00144, Italy. simona.dimartino@ifo.it.
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  Data: <searchLink fieldCode="JN" term="%228308647%22">Journal of experimental & clinical cancer research : CR</searchLink> [J Exp Clin Cancer Res] 2026 Jan 28; Vol. 45 (1). <i>Date of Electronic Publication: </i>2026 Jan 28.
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