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Neutrophil methylmalonic acid promotes microthrombus formation and adverse cardiac remodeling post-myocardial infarction through activating IL-6 signaling pathway-mediated NETosis.

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Title: Neutrophil methylmalonic acid promotes microthrombus formation and adverse cardiac remodeling post-myocardial infarction through activating IL-6 signaling pathway-mediated NETosis.
Authors: Liu Y; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Wang J; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Cai H; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Wang Z; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Lu R; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Liu X; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Wang M; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Wang W; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.; Department of Hematology, Second Affiliated Hospital of Harbin Medical University, Harbin, China., Guo J; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Ma G; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Zhang Z; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Wu P; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., She Q; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Wu X; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Xiu L; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Yu B; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China., Gao X; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China. xueqin211@126.com.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China. xueqin211@126.com., Li Z; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China. lizhaoying1990@hrbmu.edu.cn.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China. lizhaoying1990@hrbmu.edu.cn., Wang S; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China. shanjie_wang@hrbmu.edu.cn.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China. shanjie_wang@hrbmu.edu.cn., Fang S; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China. fangshaohong@hrbmu.edu.cn.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China. fangshaohong@hrbmu.edu.cn.
Source: BMC medicine [BMC Med] 2026 Jan 28; Vol. 24 (1). Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Neutrophil methylmalonic acid promotes microthrombus formation and adverse cardiac remodeling post-myocardial infarction through activating IL-6 signaling pathway-mediated NETosis.
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  Data: <searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Cai+H%22">Cai H</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Lu+R%22">Lu R</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.; Department of Hematology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Guo+J%22">Guo J</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Ma+G%22">Ma G</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Wu+P%22">Wu P</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22She+Q%22">She Q</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Xiu+L%22">Xiu L</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Yu+B%22">Yu B</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Gao+X%22">Gao X</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China. xueqin211@126.com.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China. xueqin211@126.com.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China. lizhaoying1990@hrbmu.edu.cn.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China. lizhaoying1990@hrbmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China. shanjie_wang@hrbmu.edu.cn.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China. shanjie_wang@hrbmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Fang+S%22">Fang S</searchLink>; Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China. fangshaohong@hrbmu.edu.cn.; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), the Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China. fangshaohong@hrbmu.edu.cn.
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