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Do Cenobamate Pharmacokinetics Change with Co-Administered Antiseizure Medications? An Exploratory Analysis of Responder Patients with Focal Drug-Resistant Epilepsy.

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Title: Do Cenobamate Pharmacokinetics Change with Co-Administered Antiseizure Medications? An Exploratory Analysis of Responder Patients with Focal Drug-Resistant Epilepsy.
Authors: Charlier B; Operative Unit of Clinical Pharmacology, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', 84131 Salerno, Italy.; Post-Graduate School in Clinical Pharmacology and Toxicology, University of Salerno, Baronissi, 84081 Salerno, Italy., Izzo V; Operative Unit of Clinical Pharmacology, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', 84131 Salerno, Italy.; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081 Salerno, Italy., Assenza G; Research Unit of Neurology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy.; Operative Research Unit of Neurology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy., Balsamo AC; Operative Unit of Clinical Pharmacology, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', 84131 Salerno, Italy.; Post-Graduate School in Clinical Pharmacology and Toxicology, University of Salerno, Baronissi, 84081 Salerno, Italy., Cirillo F; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.; Neurology Unit, University Hospital of Rome Tor Vergata, 00133 Rome, Italy., Coglianese A; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081 Salerno, Italy.; Post-Graduate School in Clinical Pathology and Clinical Biochemistry, University of Salerno, Baronissi, 84081 Salerno, Italy., Di Bonaventura C; Department of Human Neurosciences, Sapienza University, 00185 Rome, Italy., Fernandes M; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., Gambardella A; Department of Science of Health, School of Medicine, Magna Græcia University, 88100 Catanzaro, Italy.; Neurologic Clinic, Magna Græcia University, 88100 Catanzaro, Italy., Cerulli Irelli E; Department of Human Neurosciences, Sapienza University, 00185 Rome, Italy., Liguori C; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.; Neurology Unit, University Hospital of Rome Tor Vergata, 00133 Rome, Italy., Rufolo S; Operative Unit of Clinical Pharmacology, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', 84131 Salerno, Italy.; Post-Graduate School in Clinical Pathology and Clinical Biochemistry, University of Salerno, Baronissi, 84081 Salerno, Italy., Sammarra I; Department of Medical and Surgical Sciences, Institute of Neurology, Magna Græcia University, 88100 Catanzaro, Italy., Filippelli A; Operative Unit of Clinical Pharmacology, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', 84131 Salerno, Italy.; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081 Salerno, Italy., Operto FF; Neurologic Clinic, Magna Græcia University, 88100 Catanzaro, Italy.; Department of Medical and Surgical Sciences, Institute of Neurology, Magna Græcia University, 88100 Catanzaro, Italy.; Centre for Research in Unusual Infections, Epilepsy and Neuroscience (CRUISE), Science of Health Department, Magna Græcia University, 88100 Catanzaro, Italy.
Source: Pharmaceutics [Pharmaceutics] 2026 Jan 10; Vol. 18 (1). Date of Electronic Publication: 2026 Jan 10.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Do Cenobamate Pharmacokinetics Change with Co-Administered Antiseizure Medications? An Exploratory Analysis of Responder Patients with Focal Drug-Resistant Epilepsy.
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  Data: <searchLink fieldCode="AU" term="%22Charlier+B%22">Charlier B</searchLink>; Operative Unit of Clinical Pharmacology, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', 84131 Salerno, Italy.; Post-Graduate School in Clinical Pharmacology and Toxicology, University of Salerno, Baronissi, 84081 Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Izzo+V%22">Izzo V</searchLink>; Operative Unit of Clinical Pharmacology, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', 84131 Salerno, Italy.; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081 Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Assenza+G%22">Assenza G</searchLink>; Research Unit of Neurology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy.; Operative Research Unit of Neurology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Balsamo+AC%22">Balsamo AC</searchLink>; Operative Unit of Clinical Pharmacology, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', 84131 Salerno, Italy.; Post-Graduate School in Clinical Pharmacology and Toxicology, University of Salerno, Baronissi, 84081 Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Cirillo+F%22">Cirillo F</searchLink>; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.; Neurology Unit, University Hospital of Rome Tor Vergata, 00133 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Coglianese+A%22">Coglianese A</searchLink>; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081 Salerno, Italy.; Post-Graduate School in Clinical Pathology and Clinical Biochemistry, University of Salerno, Baronissi, 84081 Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Bonaventura+C%22">Di Bonaventura C</searchLink>; Department of Human Neurosciences, Sapienza University, 00185 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Fernandes+M%22">Fernandes M</searchLink>; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gambardella+A%22">Gambardella A</searchLink>; Department of Science of Health, School of Medicine, Magna Græcia University, 88100 Catanzaro, Italy.; Neurologic Clinic, Magna Græcia University, 88100 Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Cerulli+Irelli+E%22">Cerulli Irelli E</searchLink>; Department of Human Neurosciences, Sapienza University, 00185 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Liguori+C%22">Liguori C</searchLink>; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.; Neurology Unit, University Hospital of Rome Tor Vergata, 00133 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Rufolo+S%22">Rufolo S</searchLink>; Operative Unit of Clinical Pharmacology, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', 84131 Salerno, Italy.; Post-Graduate School in Clinical Pathology and Clinical Biochemistry, University of Salerno, Baronissi, 84081 Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Sammarra+I%22">Sammarra I</searchLink>; Department of Medical and Surgical Sciences, Institute of Neurology, Magna Græcia University, 88100 Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Filippelli+A%22">Filippelli A</searchLink>; Operative Unit of Clinical Pharmacology, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', 84131 Salerno, Italy.; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081 Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Operto+FF%22">Operto FF</searchLink>; Neurologic Clinic, Magna Græcia University, 88100 Catanzaro, Italy.; Department of Medical and Surgical Sciences, Institute of Neurology, Magna Græcia University, 88100 Catanzaro, Italy.; Centre for Research in Unusual Infections, Epilepsy and Neuroscience (CRUISE), Science of Health Department, Magna Græcia University, 88100 Catanzaro, Italy.
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