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Integrated multi-omics and single-cell analysis identify SERPINE1 as a key mediator of the inflammatory tumor microenvironment in PDAC.

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Title: Integrated multi-omics and single-cell analysis identify SERPINE1 as a key mediator of the inflammatory tumor microenvironment in PDAC.
Authors: Wang D; Department of Liver Transplantation, First Central Hospital of Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Molecular and Treatment of Liver Cancer, Tianjin First Central Hospital, Tianjin, China., Chen Q; Department of General Surgery, Peking University Third Hospital, Beijing, China., Li CM; Department of Liver Transplantation, First Central Hospital of Tianjin Medical University, Tianjin, China.; Department of General Surgery, Tianjin Fifth Central Hospital, Tianjin, China., Xie Y; Department of Liver Transplantation, First Central Hospital of Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Molecular and Treatment of Liver Cancer, Tianjin First Central Hospital, Tianjin, China., Yuan C; Department of General Surgery, Peking University Third Hospital, Beijing, China., Lang R; Department of Hepatobiliary and Pancreaticosplenic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China., Jiang WT; Department of Liver Transplantation, First Central Hospital of Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Molecular and Treatment of Liver Cancer, Tianjin First Central Hospital, Tianjin, China.
Source: Frontiers in immunology [Front Immunol] 2026 Jan 12; Vol. 16, pp. 1716878. Date of Electronic Publication: 2026 Jan 12 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrated multi-omics and single-cell analysis identify SERPINE1 as a key mediator of the inflammatory tumor microenvironment in PDAC.
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  Data: <searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Department of Liver Transplantation, First Central Hospital of Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Molecular and Treatment of Liver Cancer, Tianjin First Central Hospital, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; Department of General Surgery, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+CM%22">Li CM</searchLink>; Department of Liver Transplantation, First Central Hospital of Tianjin Medical University, Tianjin, China.; Department of General Surgery, Tianjin Fifth Central Hospital, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Xie+Y%22">Xie Y</searchLink>; Department of Liver Transplantation, First Central Hospital of Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Molecular and Treatment of Liver Cancer, Tianjin First Central Hospital, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Yuan+C%22">Yuan C</searchLink>; Department of General Surgery, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lang+R%22">Lang R</searchLink>; Department of Hepatobiliary and Pancreaticosplenic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Jiang+WT%22">Jiang WT</searchLink>; Department of Liver Transplantation, First Central Hospital of Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Molecular and Treatment of Liver Cancer, Tianjin First Central Hospital, Tianjin, China.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Jan 12; Vol. 16, pp. 1716878. <i>Date of Electronic Publication: </i>2026 Jan 12 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.3389/fimmu.2025.1716878
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      – TitleFull: Integrated multi-omics and single-cell analysis identify SERPINE1 as a key mediator of the inflammatory tumor microenvironment in PDAC.
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              Text: 2026 Jan 12
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