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Gain-of-Function Variant TRPC6 A404V Is Associated With Doxorubicin-Related Cardiomyopathy.

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Title: Gain-of-Function Variant TRPC6 A404V Is Associated With Doxorubicin-Related Cardiomyopathy.
Authors: Wu Y; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (Y.W., X.S., H.-C.L., T.L.).; Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Jiangsu Province, P.R. China (Y.W., R.-X.W.)., Sun X; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (Y.W., X.S., H.-C.L., T.L.)., Wang RX; Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Jiangsu Province, P.R. China (Y.W., R.-X.W.)., Reddy JS; Department of Quantitative Health Sciences (J.S.R.), Mayo Clinic, Jacksonville, FL., Lee HC; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (Y.W., X.S., H.-C.L., T.L.)., Norton N; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL (N.N.)., Lu T; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (Y.W., X.S., H.-C.L., T.L.).
Source: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2026 Feb; Vol. 19 (1), pp. e005334. Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101714113 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2574-8300 (Electronic) Linking ISSN: 25748300 NLM ISO Abbreviation: Circ Genom Precis Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (Y.W., X.S., H.-C.L., T.L.).; Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Jiangsu Province, P.R. China (Y.W., R.-X.W.).<br /><searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (Y.W., X.S., H.-C.L., T.L.).<br /><searchLink fieldCode="AU" term="%22Wang+RX%22">Wang RX</searchLink>; Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Jiangsu Province, P.R. China (Y.W., R.-X.W.).<br /><searchLink fieldCode="AU" term="%22Reddy+JS%22">Reddy JS</searchLink>; Department of Quantitative Health Sciences (J.S.R.), Mayo Clinic, Jacksonville, FL.<br /><searchLink fieldCode="AU" term="%22Lee+HC%22">Lee HC</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (Y.W., X.S., H.-C.L., T.L.).<br /><searchLink fieldCode="AU" term="%22Norton+N%22">Norton N</searchLink>; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL (N.N.).<br /><searchLink fieldCode="AU" term="%22Lu+T%22">Lu T</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (Y.W., X.S., H.-C.L., T.L.).
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  Data: <searchLink fieldCode="JN" term="%22101714113%22">Circulation. Genomic and precision medicine</searchLink> [Circ Genom Precis Med] 2026 Feb; Vol. 19 (1), pp. e005334. <i>Date of Electronic Publication: </i>2026 Jan 28.
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        Value: 10.1161/CIRCGEN.125.005334
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      – TitleFull: Gain-of-Function Variant TRPC6 A404V Is Associated With Doxorubicin-Related Cardiomyopathy.
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              Text: 2026 Feb
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