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Protocol for the generation and xenotransplantation of human induced pluripotent stem cell-derived neural progenitor cells into the mouse forebrain.

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Title: Protocol for the generation and xenotransplantation of human induced pluripotent stem cell-derived neural progenitor cells into the mouse forebrain.
Authors: McInvale JJ; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY 10032, USA., Ayers CE; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY 10032, USA., Sarmah H; Stem Cell Core, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY 10032, USA., Kim K; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Reinhardt P; Center for Regenerative Therapies TU Dresden (CRTD), Technische Universität Dresden, 01307 Dresden, Germany; Medical Faculty Carl Gustav Carus of TU Dresden, 01307 Dresden, Germany., Mahajan A; Department of Neurosurgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Humala N; Department of Neurosurgery, Columbia University Irving Medical Center, New York, NY 10032, USA., Corneo B; Stem Cell Core, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY 10032, USA., Sterneckert J; Center for Regenerative Therapies TU Dresden (CRTD), Technische Universität Dresden, 01307 Dresden, Germany; Medical Faculty Carl Gustav Carus of TU Dresden, 01307 Dresden, Germany., Canoll P; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Hargus G; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: gh2374@cumc.columbia.edu.
Source: STAR protocols [STAR Protoc] 2026 Mar 20; Vol. 7 (1), pp. 104305. Date of Electronic Publication: 2026 Jan 27.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22McInvale+JJ%22">McInvale JJ</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Ayers+CE%22">Ayers CE</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Sarmah+H%22">Sarmah H</searchLink>; Stem Cell Core, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Kim+K%22">Kim K</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Reinhardt+P%22">Reinhardt P</searchLink>; Center for Regenerative Therapies TU Dresden (CRTD), Technische Universität Dresden, 01307 Dresden, Germany; Medical Faculty Carl Gustav Carus of TU Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Mahajan+A%22">Mahajan A</searchLink>; Department of Neurosurgery, Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Humala+N%22">Humala N</searchLink>; Department of Neurosurgery, Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Corneo+B%22">Corneo B</searchLink>; Stem Cell Core, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Sterneckert+J%22">Sterneckert J</searchLink>; Center for Regenerative Therapies TU Dresden (CRTD), Technische Universität Dresden, 01307 Dresden, Germany; Medical Faculty Carl Gustav Carus of TU Dresden, 01307 Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Canoll+P%22">Canoll P</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Hargus+G%22">Hargus G</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: gh2374@cumc.columbia.edu.
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              Text: 2026 Mar 20
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