Diagnostic Performance of the α-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies: A Comparison Across 4 Laboratories.

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Title: Diagnostic Performance of the α-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies: A Comparison Across 4 Laboratories.
Authors: Kumar R; Department of Neurobiology Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.; Department of Medicine Huddinge, Karolinska Institutet, Sweden., Gravett S; Department of Neurobiology Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.; Cognitive Disorders Clinic, Theme Inflammation and Aging, Karolinska University Hospital-Huddinge, Stockholm, Sweden., Jelic V; Department of Neurobiology Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.; Cognitive Disorders Clinic, Theme Inflammation and Aging, Karolinska University Hospital-Huddinge, Stockholm, Sweden., Lange J; Centre for Movement Disorders, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Norway., Oftedal L; Centre for Movement Disorders, Stavanger University Hospital, Norway., Ciullini A; Unit of Laboratory Medicine, Laboratory of Clinical Pathology, IRCCS Neurologic Institute Carlo Besta, Milan, Italy., Bacınoğlu MB; Unit of Laboratory Medicine, Laboratory of Clinical Pathology, IRCCS Neurologic Institute Carlo Besta, Milan, Italy., De Luca CMG; Department of Neurology 5 - Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Hamied L; Laboratory of Biochemistry and Molecular Biology, University Hospital of Strasbourg, Hautepierre Hospital, France., Birck C; Plateforme de Biologie Structurale Intégrée (BSI-FRISBI), CBI-IGBMC, CNRS UMR 7104, Inserm U1258, University of Strasbourg, Illkirch, France., Blanc F; University Hospitals of Strasbourg, CM2R (Research and Resources Memory Center), Day Hospitals, Service of Gerontology Mobile-Neuro-Psy-Research, GeRMINED Department, France.; University of Strasbourg and CNRS, ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), IMIS Team, France., Hoede PL; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, the Netherlands., Lemstra AW; Alzheimer Center, Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, the Netherlands., Gonzalez MC; Centre for Age-Related Medicine, Stavanger University Hospital, Norway., Aarsland D; Centre for Age-Related Medicine, Stavanger University Hospital, Norway.; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom., Teunissen CE; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, the Netherlands., Bousiges O; Laboratory of Biochemistry and Molecular Biology, University Hospital of Strasbourg, Hautepierre Hospital, France.; University of Strasbourg and CNRS, ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), IMIS Team, France., Moda F; Unit of Laboratory Medicine, Laboratory of Clinical Pathology, IRCCS Neurologic Institute Carlo Besta, Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy; and., Maple-Grødem J; Centre for Movement Disorders, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Norway., Abelein A; Department of Medicine Huddinge, Karolinska Institutet, Sweden., Ferreira D; Department of Neurobiology Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.; Facultad de Ciencias de la Salud, Universidad Fernando Pessoa Canarias, Las Palmas, Spain.
Source: Neurology [Neurology] 2026 Feb 24; Vol. 106 (4), pp. e214614. Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article; Comparative Study; Multicenter Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1526-632X
DOI:10.1212/WNL.0000000000214614