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Diagnostic Performance of the α-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies: A Comparison Across 4 Laboratories.

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Title: Diagnostic Performance of the α-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies: A Comparison Across 4 Laboratories.
Authors: Kumar R; Department of Neurobiology Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.; Department of Medicine Huddinge, Karolinska Institutet, Sweden., Gravett S; Department of Neurobiology Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.; Cognitive Disorders Clinic, Theme Inflammation and Aging, Karolinska University Hospital-Huddinge, Stockholm, Sweden., Jelic V; Department of Neurobiology Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.; Cognitive Disorders Clinic, Theme Inflammation and Aging, Karolinska University Hospital-Huddinge, Stockholm, Sweden., Lange J; Centre for Movement Disorders, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Norway., Oftedal L; Centre for Movement Disorders, Stavanger University Hospital, Norway., Ciullini A; Unit of Laboratory Medicine, Laboratory of Clinical Pathology, IRCCS Neurologic Institute Carlo Besta, Milan, Italy., Bacınoğlu MB; Unit of Laboratory Medicine, Laboratory of Clinical Pathology, IRCCS Neurologic Institute Carlo Besta, Milan, Italy., De Luca CMG; Department of Neurology 5 - Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Hamied L; Laboratory of Biochemistry and Molecular Biology, University Hospital of Strasbourg, Hautepierre Hospital, France., Birck C; Plateforme de Biologie Structurale Intégrée (BSI-FRISBI), CBI-IGBMC, CNRS UMR 7104, Inserm U1258, University of Strasbourg, Illkirch, France., Blanc F; University Hospitals of Strasbourg, CM2R (Research and Resources Memory Center), Day Hospitals, Service of Gerontology Mobile-Neuro-Psy-Research, GeRMINED Department, France.; University of Strasbourg and CNRS, ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), IMIS Team, France., Hoede PL; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, the Netherlands., Lemstra AW; Alzheimer Center, Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, the Netherlands., Gonzalez MC; Centre for Age-Related Medicine, Stavanger University Hospital, Norway., Aarsland D; Centre for Age-Related Medicine, Stavanger University Hospital, Norway.; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom., Teunissen CE; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, the Netherlands., Bousiges O; Laboratory of Biochemistry and Molecular Biology, University Hospital of Strasbourg, Hautepierre Hospital, France.; University of Strasbourg and CNRS, ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), IMIS Team, France., Moda F; Unit of Laboratory Medicine, Laboratory of Clinical Pathology, IRCCS Neurologic Institute Carlo Besta, Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy; and., Maple-Grødem J; Centre for Movement Disorders, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Norway., Abelein A; Department of Medicine Huddinge, Karolinska Institutet, Sweden., Ferreira D; Department of Neurobiology Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.; Facultad de Ciencias de la Salud, Universidad Fernando Pessoa Canarias, Las Palmas, Spain.
Source: Neurology [Neurology] 2026 Feb 24; Vol. 106 (4), pp. e214614. Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article; Comparative Study; Multicenter Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE
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  Data: Diagnostic Performance of the α-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies: A Comparison Across 4 Laboratories.
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  Data: <searchLink fieldCode="AU" term="%22Kumar+R%22">Kumar R</searchLink>; Department of Neurobiology Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.; Department of Medicine Huddinge, Karolinska Institutet, Sweden.<br /><searchLink fieldCode="AU" term="%22Gravett+S%22">Gravett S</searchLink>; Department of Neurobiology Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.; Cognitive Disorders Clinic, Theme Inflammation and Aging, Karolinska University Hospital-Huddinge, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Jelic+V%22">Jelic V</searchLink>; Department of Neurobiology Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.; Cognitive Disorders Clinic, Theme Inflammation and Aging, Karolinska University Hospital-Huddinge, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Lange+J%22">Lange J</searchLink>; Centre for Movement Disorders, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Norway.<br /><searchLink fieldCode="AU" term="%22Oftedal+L%22">Oftedal L</searchLink>; Centre for Movement Disorders, Stavanger University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Ciullini+A%22">Ciullini A</searchLink>; Unit of Laboratory Medicine, Laboratory of Clinical Pathology, IRCCS Neurologic Institute Carlo Besta, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bacınoğlu+MB%22">Bacınoğlu MB</searchLink>; Unit of Laboratory Medicine, Laboratory of Clinical Pathology, IRCCS Neurologic Institute Carlo Besta, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Luca+CMG%22">De Luca CMG</searchLink>; Department of Neurology 5 - Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Hamied+L%22">Hamied L</searchLink>; Laboratory of Biochemistry and Molecular Biology, University Hospital of Strasbourg, Hautepierre Hospital, France.<br /><searchLink fieldCode="AU" term="%22Birck+C%22">Birck C</searchLink>; Plateforme de Biologie Structurale Intégrée (BSI-FRISBI), CBI-IGBMC, CNRS UMR 7104, Inserm U1258, University of Strasbourg, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Blanc+F%22">Blanc F</searchLink>; University Hospitals of Strasbourg, CM2R (Research and Resources Memory Center), Day Hospitals, Service of Gerontology Mobile-Neuro-Psy-Research, GeRMINED Department, France.; University of Strasbourg and CNRS, ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), IMIS Team, France.<br /><searchLink fieldCode="AU" term="%22Hoede+PL%22">Hoede PL</searchLink>; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lemstra+AW%22">Lemstra AW</searchLink>; Alzheimer Center, Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gonzalez+MC%22">Gonzalez MC</searchLink>; Centre for Age-Related Medicine, Stavanger University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Aarsland+D%22">Aarsland D</searchLink>; Centre for Age-Related Medicine, Stavanger University Hospital, Norway.; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Teunissen+CE%22">Teunissen CE</searchLink>; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bousiges+O%22">Bousiges O</searchLink>; Laboratory of Biochemistry and Molecular Biology, University Hospital of Strasbourg, Hautepierre Hospital, France.; University of Strasbourg and CNRS, ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), IMIS Team, France.<br /><searchLink fieldCode="AU" term="%22Moda+F%22">Moda F</searchLink>; Unit of Laboratory Medicine, Laboratory of Clinical Pathology, IRCCS Neurologic Institute Carlo Besta, Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy; and.<br /><searchLink fieldCode="AU" term="%22Maple-Grødem+J%22">Maple-Grødem J</searchLink>; Centre for Movement Disorders, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Norway.<br /><searchLink fieldCode="AU" term="%22Abelein+A%22">Abelein A</searchLink>; Department of Medicine Huddinge, Karolinska Institutet, Sweden.<br /><searchLink fieldCode="AU" term="%22Ferreira+D%22">Ferreira D</searchLink>; Department of Neurobiology Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.; Facultad de Ciencias de la Salud, Universidad Fernando Pessoa Canarias, Las Palmas, Spain.
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  Data: <searchLink fieldCode="JN" term="%220401060%22">Neurology</searchLink> [Neurology] 2026 Feb 24; Vol. 106 (4), pp. e214614. <i>Date of Electronic Publication: </i>2026 Jan 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0401060 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1526-632X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200283878%22">00283878 </searchLink><i>NLM ISO Abbreviation: </i>Neurology <i>Subsets: </i>MEDLINE
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