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Breaking the PROMISE: poor association between brain volume loss and clinical disability worsening over 2 years of follow-up in primary progressive multiple sclerosis.

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Title: Breaking the PROMISE: poor association between brain volume loss and clinical disability worsening over 2 years of follow-up in primary progressive multiple sclerosis.
Authors: Koch M; Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada mwkoch@ucalgary.ca., Mostert J; Neurology, Rijnstate Hospital Arnhem, Arnhem, Netherlands., Strijbis EM; Neurology, Amsterdam UMC - Locatie VUMC, Amsterdam, Netherlands., D'Haeseleer M; Department of Neurology, National MS Center Melsbroek, Melsbroek, Belgium.; Neurology, Vrije Universiteit Brussel, Brussels, Belgium., Torkildsen Ø; Department of Neurology, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway., Comtois J; Médecine, service de neurologie, Hôpital Cité-de-la-Santé de Laval, Laval, Alberta, Canada.; Neurosciences, Université de Montréal, Montreal, Québec, Canada., Repovic P; Swedish Neuroscience Institute, Seattle, Washington, USA., Uitdehaag BMJ; Neurology, Amsterdam UMC, Amsterdam, Netherlands., Killestein J; Amsterdam UMC - Locatie VUMC, Amsterdam, Netherlands., Mcpherson T; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA., Cutter G; UAB School of Public Health, Birmingham, Alabama, USA.
Source: Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2026 Apr 15; Vol. 97 (5), pp. 422-430. Date of Electronic Publication: 2026 Apr 15.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 2985191R Publication Model: Electronic Cited Medium: Internet ISSN: 1468-330X (Electronic) Linking ISSN: 00223050 NLM ISO Abbreviation: J Neurol Neurosurg Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Breaking the PROMISE: poor association between brain volume loss and clinical disability worsening over 2 years of follow-up in primary progressive multiple sclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Koch+M%22">Koch M</searchLink>; Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada mwkoch@ucalgary.ca.<br /><searchLink fieldCode="AU" term="%22Mostert+J%22">Mostert J</searchLink>; Neurology, Rijnstate Hospital Arnhem, Arnhem, Netherlands.<br /><searchLink fieldCode="AU" term="%22Strijbis+EM%22">Strijbis EM</searchLink>; Neurology, Amsterdam UMC - Locatie VUMC, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22D'Haeseleer+M%22">D'Haeseleer M</searchLink>; Department of Neurology, National MS Center Melsbroek, Melsbroek, Belgium.; Neurology, Vrije Universiteit Brussel, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Torkildsen+Ø%22">Torkildsen Ø</searchLink>; Department of Neurology, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Comtois+J%22">Comtois J</searchLink>; Médecine, service de neurologie, Hôpital Cité-de-la-Santé de Laval, Laval, Alberta, Canada.; Neurosciences, Université de Montréal, Montreal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Repovic+P%22">Repovic P</searchLink>; Swedish Neuroscience Institute, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Uitdehaag+BMJ%22">Uitdehaag BMJ</searchLink>; Neurology, Amsterdam UMC, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Killestein+J%22">Killestein J</searchLink>; Amsterdam UMC - Locatie VUMC, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Mcpherson+T%22">Mcpherson T</searchLink>; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Cutter+G%22">Cutter G</searchLink>; UAB School of Public Health, Birmingham, Alabama, USA.
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  Data: <searchLink fieldCode="JN" term="%222985191R%22">Journal of neurology, neurosurgery, and psychiatry</searchLink> [J Neurol Neurosurg Psychiatry] 2026 Apr 15; Vol. 97 (5), pp. 422-430. <i>Date of Electronic Publication: </i>2026 Apr 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group%22">BMJ Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985191R <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1468-330X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200223050%22">00223050 </searchLink><i>NLM ISO Abbreviation: </i>J Neurol Neurosurg Psychiatry <i>Subsets: </i>MEDLINE
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        Value: 10.1136/jnnp-2025-337940
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              Text: 2026 Apr 15
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