PAF15-PCNA exhaustion governs the strand-specific control of DNA replication.

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Title: PAF15-PCNA exhaustion governs the strand-specific control of DNA replication.
Authors: Chhetri G; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Badugu SB; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Petriman NA; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Petersen MB; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Güller AS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Fajri N; Genome Integrity and Cancers, Gustave Roussy, Université Paris-Saclay, CNRS, Villejuif, France., Coulée M; Genome Integrity and Cancers, Gustave Roussy, Université Paris-Saclay, CNRS, Villejuif, France., Pitchai GP; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Novotný J; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Larsen FT; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark., Møller AF; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, USA., Ebbesen MF; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Ravnsborg T; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Yadav AK; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic., Balarasa B; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Lunding A; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Polasek-Sedlackova H; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic., Jensen ON; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Ravnskjaer K; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark., Brewer JR; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark., Madsen JGS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, USA., Petryk N; Genome Integrity and Cancers, Gustave Roussy, Université Paris-Saclay, CNRS, Villejuif, France., Andersen JS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Somyajit K; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark. ksom@sdu.dk.
Source: Nature [Nature] 2026 Mar; Vol. 651 (8105), pp. 521-532. Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Chhetri+G%22">Chhetri G</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Badugu+SB%22">Badugu SB</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Petriman+NA%22">Petriman NA</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Petersen+MB%22">Petersen MB</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Güller+AS%22">Güller AS</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Fajri+N%22">Fajri N</searchLink>; Genome Integrity and Cancers, Gustave Roussy, Université Paris-Saclay, CNRS, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Coulée+M%22">Coulée M</searchLink>; Genome Integrity and Cancers, Gustave Roussy, Université Paris-Saclay, CNRS, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Pitchai+GP%22">Pitchai GP</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Novotný+J%22">Novotný J</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Larsen+FT%22">Larsen FT</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Møller+AF%22">Møller AF</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, USA.<br /><searchLink fieldCode="AU" term="%22Ebbesen+MF%22">Ebbesen MF</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Ravnsborg+T%22">Ravnsborg T</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Yadav+AK%22">Yadav AK</searchLink>; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Balarasa+B%22">Balarasa B</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Lunding+A%22">Lunding A</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Polasek-Sedlackova+H%22">Polasek-Sedlackova H</searchLink>; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Jensen+ON%22">Jensen ON</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Ravnskjaer+K%22">Ravnskjaer K</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Brewer+JR%22">Brewer JR</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Madsen+JGS%22">Madsen JGS</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, USA.<br /><searchLink fieldCode="AU" term="%22Petryk+N%22">Petryk N</searchLink>; Genome Integrity and Cancers, Gustave Roussy, Université Paris-Saclay, CNRS, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Andersen+JS%22">Andersen JS</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Somyajit+K%22">Somyajit K</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark. ksom@sdu.dk.
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