PAF15-PCNA exhaustion governs the strand-specific control of DNA replication.

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Title: PAF15-PCNA exhaustion governs the strand-specific control of DNA replication.
Authors: Chhetri G; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Badugu SB; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Petriman NA; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Petersen MB; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Güller AS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Fajri N; Genome Integrity and Cancers, Gustave Roussy, Université Paris-Saclay, CNRS, Villejuif, France., Coulée M; Genome Integrity and Cancers, Gustave Roussy, Université Paris-Saclay, CNRS, Villejuif, France., Pitchai GP; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Novotný J; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Larsen FT; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark., Møller AF; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, USA., Ebbesen MF; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Ravnsborg T; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Yadav AK; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic., Balarasa B; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Lunding A; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Polasek-Sedlackova H; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic., Jensen ON; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Ravnskjaer K; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark., Brewer JR; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark., Madsen JGS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, USA., Petryk N; Genome Integrity and Cancers, Gustave Roussy, Université Paris-Saclay, CNRS, Villejuif, France., Andersen JS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Somyajit K; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark. ksom@sdu.dk.
Source: Nature [Nature] 2026 Mar; Vol. 651 (8105), pp. 521-532. Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-025-10011-3