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Pre-assembly of biomolecular condensate seeds drives RSV replication.

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Title: Pre-assembly of biomolecular condensate seeds drives RSV replication.
Authors: Ratnayake D; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands., Galloux M; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France., Boersma S; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands., Noerenberg M; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., Sizun C; Institut de Chimie des Substances Naturelles, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France., Sacristan C; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands., Sourimant J; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France., Lakerveld AJ; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Gelderloos AT; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Apperloo L; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands., Demyanenko Y; The Rosalind Franklin Institute, Didcot, UK., Baars MJD; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands., Banerjee R; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands., Dreier B; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Furler S; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Mazur NI; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, the Netherlands.; Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands., Bont LJ; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, the Netherlands.; Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.; Respiratory Syncytial Virus Network (ResViNET) Foundation, Zeist, the Netherlands., Mohammed S; Department of Biochemistry, University of Oxford, Oxford, UK.; The Rosalind Franklin Institute, Didcot, UK.; Department of Chemistry, University of Oxford, Oxford, UK., Plückthun A; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Éléouët JF; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France., Kops GJPL; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands., Castello A; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., van Kasteren PB; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands., Rameix-Welti MA; M3P unit, Institut Pasteur, Université Paris Cité, Paris, France.; UMR 1173 (2I), INSERM, Université de Versailles St. Quentin, Université Paris-Saclay, Paris, France.; Hôpital Ambroise Paré, Assistance Publique des Hôpitaux de Paris, Paris, France., Tanenbaum ME; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands. m.tanenbaum@hubrecht.eu.; Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Technische Universiteit Delft, Delft, the Netherlands. m.tanenbaum@hubrecht.eu.
Source: Nature [Nature] 2026 Apr; Vol. 652 (8108), pp. 189-200. Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pre-assembly of biomolecular condensate seeds drives RSV replication.
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  Data: <searchLink fieldCode="AU" term="%22Ratnayake+D%22">Ratnayake D</searchLink>; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Galloux+M%22">Galloux M</searchLink>; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.<br /><searchLink fieldCode="AU" term="%22Boersma+S%22">Boersma S</searchLink>; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Noerenberg+M%22">Noerenberg M</searchLink>; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.; Department of Biochemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Sizun+C%22">Sizun C</searchLink>; Institut de Chimie des Substances Naturelles, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.<br /><searchLink fieldCode="AU" term="%22Sacristan+C%22">Sacristan C</searchLink>; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sourimant+J%22">Sourimant J</searchLink>; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.<br /><searchLink fieldCode="AU" term="%22Lakerveld+AJ%22">Lakerveld AJ</searchLink>; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gelderloos+AT%22">Gelderloos AT</searchLink>; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Apperloo+L%22">Apperloo L</searchLink>; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Demyanenko+Y%22">Demyanenko Y</searchLink>; The Rosalind Franklin Institute, Didcot, UK.<br /><searchLink fieldCode="AU" term="%22Baars+MJD%22">Baars MJD</searchLink>; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Banerjee+R%22">Banerjee R</searchLink>; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Dreier+B%22">Dreier B</searchLink>; Department of Biochemistry, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Furler+S%22">Furler S</searchLink>; Department of Biochemistry, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mazur+NI%22">Mazur NI</searchLink>; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, the Netherlands.; Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bont+LJ%22">Bont LJ</searchLink>; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, the Netherlands.; Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.; Respiratory Syncytial Virus Network (ResViNET) Foundation, Zeist, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mohammed+S%22">Mohammed S</searchLink>; Department of Biochemistry, University of Oxford, Oxford, UK.; The Rosalind Franklin Institute, Didcot, UK.; Department of Chemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Plückthun+A%22">Plückthun A</searchLink>; Department of Biochemistry, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Éléouët+JF%22">Éléouët JF</searchLink>; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.<br /><searchLink fieldCode="AU" term="%22Kops+GJPL%22">Kops GJPL</searchLink>; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Castello+A%22">Castello A</searchLink>; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.; Department of Biochemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22van+Kasteren+PB%22">van Kasteren PB</searchLink>; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rameix-Welti+MA%22">Rameix-Welti MA</searchLink>; M3P unit, Institut Pasteur, Université Paris Cité, Paris, France.; UMR 1173 (2I), INSERM, Université de Versailles St. Quentin, Université Paris-Saclay, Paris, France.; Hôpital Ambroise Paré, Assistance Publique des Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Tanenbaum+ME%22">Tanenbaum ME</searchLink>; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands. m.tanenbaum@hubrecht.eu.; Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Technische Universiteit Delft, Delft, the Netherlands. m.tanenbaum@hubrecht.eu.
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