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Presymptomatic pharmacological inhibition of mGluR5 improves survival in a mouse model of prion diseases.

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Title: Presymptomatic pharmacological inhibition of mGluR5 improves survival in a mouse model of prion diseases.
Authors: Wang Y; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mohammadi B; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hartmann C; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Klinik und Poliklinik für Neurologie, Universitätsmedizin Rostock, Gehlsheimer Straße 20, 18147, Rostock, Germany., Hartmann K; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Thies E; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Matamoros-Angles A; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Faculty of Medicine University of Vic-Central University of Catalonia (UVic-UCC), 08500, Vic, Barcelona, Spain., Fang C; Department of Biochemistry and Cell Biology, Boston University/Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Annovis Bio, 101 Lindenwood Dr., PA 19355, Malvern, USA., Harris DA; Department of Biochemistry and Cell Biology, Boston University/Chobanian & Avedisian School of Medicine, Boston, MA, USA., Tatzelt J; Department of Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.; Cluster of Excellence RESOLV, Ruhr University Bochum, Bochum, Germany., Altmeppen HC; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sepulveda-Falla D; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Strittmatter SM; Departments of Neuroscience and Neurology, Yale School of Medicine, New Haven, USA., Glatzel M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Krasemann S; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. s.krasemann@uke.de.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Jan 29; Vol. 14 (1). Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Presymptomatic pharmacological inhibition of mGluR5 improves survival in a mouse model of prion diseases.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mohammadi+B%22">Mohammadi B</searchLink>; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hartmann+C%22">Hartmann C</searchLink>; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Klinik und Poliklinik für Neurologie, Universitätsmedizin Rostock, Gehlsheimer Straße 20, 18147, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Hartmann+K%22">Hartmann K</searchLink>; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Thies+E%22">Thies E</searchLink>; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Matamoros-Angles+A%22">Matamoros-Angles A</searchLink>; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Faculty of Medicine University of Vic-Central University of Catalonia (UVic-UCC), 08500, Vic, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fang+C%22">Fang C</searchLink>; Department of Biochemistry and Cell Biology, Boston University/Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Annovis Bio, 101 Lindenwood Dr., PA 19355, Malvern, USA.<br /><searchLink fieldCode="AU" term="%22Harris+DA%22">Harris DA</searchLink>; Department of Biochemistry and Cell Biology, Boston University/Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tatzelt+J%22">Tatzelt J</searchLink>; Department of Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.; Cluster of Excellence RESOLV, Ruhr University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Altmeppen+HC%22">Altmeppen HC</searchLink>; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sepulveda-Falla+D%22">Sepulveda-Falla D</searchLink>; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Strittmatter+SM%22">Strittmatter SM</searchLink>; Departments of Neuroscience and Neurology, Yale School of Medicine, New Haven, USA.<br /><searchLink fieldCode="AU" term="%22Glatzel+M%22">Glatzel M</searchLink>; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Krasemann+S%22">Krasemann S</searchLink>; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. s.krasemann@uke.de.
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  Data: <searchLink fieldCode="JN" term="%22101610673%22">Acta neuropathologica communications</searchLink> [Acta Neuropathol Commun] 2026 Jan 29; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 Jan 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101610673 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-5960 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220515960%22">20515960 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol Commun <i>Subsets: </i>MEDLINE
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