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Targeting the Membrane-Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight.

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Title: Targeting the Membrane-Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight.
Authors: Bohg C; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Dubanych Y; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.; Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Prague, Czech Republic., Kosteletos S; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Xiao T; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Neuenschwander M; Core Facility Screening Unit, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Utesch T; Research Unit Structural Chemistry & Computational Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Lisurek M; Research Unit Structural Chemistry & Computational Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Öster C; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Oder A; Core Facility Screening Unit, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Seyffarth C; Core Facility Screening Unit, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Bach K; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic., Leone DG; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic., Filandr F; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic., Wegert M; Research Unit Biomolecule Modification and Delivery, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Lange S; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Sawczyc H; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., von Kries JP; Core Facility Screening Unit, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Hackenberger CPR; Research Unit Biomolecule Modification and Delivery, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.; Institute of Chemistry, Humboldt-Universität zu Berlin, Berlin, Germany., Specker E; Core Facility Compound Management, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Sun H; Research Unit Structural Chemistry & Computational Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.; Institute of Chemistry, Technische Universität Berlin, Berlin, Germany., Stříšovský K; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic., Lange A; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.; Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
Source: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2026 Mar 02; Vol. 65 (10), pp. e14067. Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Bohg+C%22">Bohg C</searchLink>; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Dubanych+Y%22">Dubanych Y</searchLink>; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.; Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kosteletos+S%22">Kosteletos S</searchLink>; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Xiao+T%22">Xiao T</searchLink>; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Neuenschwander+M%22">Neuenschwander M</searchLink>; Core Facility Screening Unit, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Utesch+T%22">Utesch T</searchLink>; Research Unit Structural Chemistry & Computational Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lisurek+M%22">Lisurek M</searchLink>; Research Unit Structural Chemistry & Computational Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Öster+C%22">Öster C</searchLink>; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Oder+A%22">Oder A</searchLink>; Core Facility Screening Unit, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Seyffarth+C%22">Seyffarth C</searchLink>; Core Facility Screening Unit, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Bach+K%22">Bach K</searchLink>; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Leone+DG%22">Leone DG</searchLink>; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Filandr+F%22">Filandr F</searchLink>; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Wegert+M%22">Wegert M</searchLink>; Research Unit Biomolecule Modification and Delivery, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Lange+S%22">Lange S</searchLink>; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sawczyc+H%22">Sawczyc H</searchLink>; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22von+Kries+JP%22">von Kries JP</searchLink>; Core Facility Screening Unit, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hackenberger+CPR%22">Hackenberger CPR</searchLink>; Research Unit Biomolecule Modification and Delivery, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.; Institute of Chemistry, Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Specker+E%22">Specker E</searchLink>; Core Facility Compound Management, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sun+H%22">Sun H</searchLink>; Research Unit Structural Chemistry & Computational Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.; Institute of Chemistry, Technische Universität Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Stříšovský+K%22">Stříšovský K</searchLink>; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Lange+A%22">Lange A</searchLink>; Research Unit Molecular Biophysics, Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.; Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
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