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Comparative risk of systemic autoimmune diseases in juvenile idiopathic arthritis treated with TNF-α or IL-6 inhibitors: a real-world cohort study.

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Title: Comparative risk of systemic autoimmune diseases in juvenile idiopathic arthritis treated with TNF-α or IL-6 inhibitors: a real-world cohort study.
Authors: Tsai JJ; Tropical Medicine Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Liu LT; Department of Medical Laboratory Science and Biotechnology, College of Medical Technology, Chung Hwa University of Medical Technology, Tainan, Taiwan., Lin PC; Tropical Medicine Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan., Wang YH; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan., Lee YH; Department of Orthopedics, Feng Yuan Hospital, Ministry of Health and Welfare, Taichung, Taiwan.; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan.; Department of Senior Services Industry Management, Minghsin University of Science and Technology, Hsinchu, Taiwan.; Department of Recreation and Sport Management, Shu-Te University, Kaohsiung, Taiwan., Wei JC; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan.; Office of Research and Development, Asia University, Taichung, Taiwan.; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.
Source: Frontiers in immunology [Front Immunol] 2026 Jan 13; Vol. 16, pp. 1744226. Date of Electronic Publication: 2026 Jan 13 (Print Publication: 2025).
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Comparative risk of systemic autoimmune diseases in juvenile idiopathic arthritis treated with TNF-α or IL-6 inhibitors: a real-world cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Tsai+JJ%22">Tsai JJ</searchLink>; Tropical Medicine Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+LT%22">Liu LT</searchLink>; Department of Medical Laboratory Science and Biotechnology, College of Medical Technology, Chung Hwa University of Medical Technology, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+PC%22">Lin PC</searchLink>; Tropical Medicine Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+YH%22">Wang YH</searchLink>; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+YH%22">Lee YH</searchLink>; Department of Orthopedics, Feng Yuan Hospital, Ministry of Health and Welfare, Taichung, Taiwan.; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan.; Department of Senior Services Industry Management, Minghsin University of Science and Technology, Hsinchu, Taiwan.; Department of Recreation and Sport Management, Shu-Te University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wei+JC%22">Wei JC</searchLink>; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan.; Office of Research and Development, Asia University, Taichung, Taiwan.; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Jan 13; Vol. 16, pp. 1744226. <i>Date of Electronic Publication: </i>2026 Jan 13 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.3389/fimmu.2025.1744226
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        Text: English
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              Text: 2026 Jan 13
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