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Production and characterization of rNGFSP: a recombinant fusion immunogen eliciting dual anti-NGF and anti-Substance P therapeutic antibodies for Degenerative Joint Disease.

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Title: Production and characterization of rNGFSP: a recombinant fusion immunogen eliciting dual anti-NGF and anti-Substance P therapeutic antibodies for Degenerative Joint Disease.
Authors: Varela V; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Neurodegeneration Lab, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay., Costa M; Xeptiva Therapeutics, Montevideo 11.300, Uruguay., Maciel C; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Neurodegeneration Lab, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay., Barbeito J; Xeptiva Therapeutics, Montevideo 11.300, Uruguay., Barrera EE; Instituto de Histología y Embriología de Mendoza (IHEM), Universidad Nacional de Cuyo, CONICET, Mendoza, Argentina., Gutierre E; Unidad de Farmacología, Departamento de Clínicas y Hospital Veterinario, Facultad de Veterinaria, UdelaR, Montevideo 13.000, Uruguay., Correa A; Protein Engineering Unit, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay., Elgue M; Xeptiva Therapeutics, Montevideo 11.300, Uruguay., Carrasco S; Unidad de Farmacología, Departamento de Clínicas y Hospital Veterinario, Facultad de Veterinaria, UdelaR, Montevideo 13.000, Uruguay., Larrosa MD; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Unidad de Clínica y Cirugía de Pequeños Animales, Facultad de Veterinaria, UdelaR, Montevideo 13000, Uruguay., Pereira M; Xeptiva Therapeutics, Montevideo 11.300, Uruguay., Correa J; Xeptiva Therapeutics, Montevideo 11.300, Uruguay., Crosignani N; Unidad de Farmacología, Departamento de Clínicas y Hospital Veterinario, Facultad de Veterinaria, UdelaR, Montevideo 13.000, Uruguay., Beckman JS; e-MSion Inc., 2121 NE Jack London Street, Corvallis, OR 97330, United States.; Linus Pauling Institute, Department of Biochemistry and Biophysics, Oregon State University, 97331, United States., Barbeito L; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Neurodegeneration Lab, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay., Trias E; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Neurodegeneration Lab, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay.
Source: Biotechnology reports (Amsterdam, Netherlands) [Biotechnol Rep (Amst)] 2026 Jan 12; Vol. 49, pp. e00946. Date of Electronic Publication: 2026 Jan 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B. V Country of Publication: Netherlands NLM ID: 101637426 Publication Model: eCollection Cited Medium: Print ISSN: 2215-017X (Print) Linking ISSN: 2215017X NLM ISO Abbreviation: Biotechnol Rep (Amst) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Production and characterization of rNGFSP: a recombinant fusion immunogen eliciting dual anti-NGF and anti-Substance P therapeutic antibodies for Degenerative Joint Disease.
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  Data: <searchLink fieldCode="AU" term="%22Varela+V%22">Varela V</searchLink>; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Neurodegeneration Lab, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay.<br /><searchLink fieldCode="AU" term="%22Costa+M%22">Costa M</searchLink>; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.<br /><searchLink fieldCode="AU" term="%22Maciel+C%22">Maciel C</searchLink>; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Neurodegeneration Lab, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay.<br /><searchLink fieldCode="AU" term="%22Barbeito+J%22">Barbeito J</searchLink>; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.<br /><searchLink fieldCode="AU" term="%22Barrera+EE%22">Barrera EE</searchLink>; Instituto de Histología y Embriología de Mendoza (IHEM), Universidad Nacional de Cuyo, CONICET, Mendoza, Argentina.<br /><searchLink fieldCode="AU" term="%22Gutierre+E%22">Gutierre E</searchLink>; Unidad de Farmacología, Departamento de Clínicas y Hospital Veterinario, Facultad de Veterinaria, UdelaR, Montevideo 13.000, Uruguay.<br /><searchLink fieldCode="AU" term="%22Correa+A%22">Correa A</searchLink>; Protein Engineering Unit, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay.<br /><searchLink fieldCode="AU" term="%22Elgue+M%22">Elgue M</searchLink>; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.<br /><searchLink fieldCode="AU" term="%22Carrasco+S%22">Carrasco S</searchLink>; Unidad de Farmacología, Departamento de Clínicas y Hospital Veterinario, Facultad de Veterinaria, UdelaR, Montevideo 13.000, Uruguay.<br /><searchLink fieldCode="AU" term="%22Larrosa+MD%22">Larrosa MD</searchLink>; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Unidad de Clínica y Cirugía de Pequeños Animales, Facultad de Veterinaria, UdelaR, Montevideo 13000, Uruguay.<br /><searchLink fieldCode="AU" term="%22Pereira+M%22">Pereira M</searchLink>; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.<br /><searchLink fieldCode="AU" term="%22Correa+J%22">Correa J</searchLink>; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.<br /><searchLink fieldCode="AU" term="%22Crosignani+N%22">Crosignani N</searchLink>; Unidad de Farmacología, Departamento de Clínicas y Hospital Veterinario, Facultad de Veterinaria, UdelaR, Montevideo 13.000, Uruguay.<br /><searchLink fieldCode="AU" term="%22Beckman+JS%22">Beckman JS</searchLink>; e-MSion Inc., 2121 NE Jack London Street, Corvallis, OR 97330, United States.; Linus Pauling Institute, Department of Biochemistry and Biophysics, Oregon State University, 97331, United States.<br /><searchLink fieldCode="AU" term="%22Barbeito+L%22">Barbeito L</searchLink>; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Neurodegeneration Lab, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay.<br /><searchLink fieldCode="AU" term="%22Trias+E%22">Trias E</searchLink>; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Neurodegeneration Lab, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay.
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  Data: <searchLink fieldCode="JN" term="%22101637426%22">Biotechnology reports (Amsterdam, Netherlands)</searchLink> [Biotechnol Rep (Amst)] 2026 Jan 12; Vol. 49, pp. e00946. <i>Date of Electronic Publication: </i>2026 Jan 12 (<i>Print Publication: </i>2026).
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