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Production and characterization of rNGFSP: a recombinant fusion immunogen eliciting dual anti-NGF and anti-Substance P therapeutic antibodies for Degenerative Joint Disease.

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Title: Production and characterization of rNGFSP: a recombinant fusion immunogen eliciting dual anti-NGF and anti-Substance P therapeutic antibodies for Degenerative Joint Disease.
Authors: Varela V; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Neurodegeneration Lab, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay., Costa M; Xeptiva Therapeutics, Montevideo 11.300, Uruguay., Maciel C; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Neurodegeneration Lab, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay., Barbeito J; Xeptiva Therapeutics, Montevideo 11.300, Uruguay., Barrera EE; Instituto de Histología y Embriología de Mendoza (IHEM), Universidad Nacional de Cuyo, CONICET, Mendoza, Argentina., Gutierre E; Unidad de Farmacología, Departamento de Clínicas y Hospital Veterinario, Facultad de Veterinaria, UdelaR, Montevideo 13.000, Uruguay., Correa A; Protein Engineering Unit, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay., Elgue M; Xeptiva Therapeutics, Montevideo 11.300, Uruguay., Carrasco S; Unidad de Farmacología, Departamento de Clínicas y Hospital Veterinario, Facultad de Veterinaria, UdelaR, Montevideo 13.000, Uruguay., Larrosa MD; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Unidad de Clínica y Cirugía de Pequeños Animales, Facultad de Veterinaria, UdelaR, Montevideo 13000, Uruguay., Pereira M; Xeptiva Therapeutics, Montevideo 11.300, Uruguay., Correa J; Xeptiva Therapeutics, Montevideo 11.300, Uruguay., Crosignani N; Unidad de Farmacología, Departamento de Clínicas y Hospital Veterinario, Facultad de Veterinaria, UdelaR, Montevideo 13.000, Uruguay., Beckman JS; e-MSion Inc., 2121 NE Jack London Street, Corvallis, OR 97330, United States.; Linus Pauling Institute, Department of Biochemistry and Biophysics, Oregon State University, 97331, United States., Barbeito L; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Neurodegeneration Lab, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay., Trias E; Xeptiva Therapeutics, Montevideo 11.300, Uruguay.; Neurodegeneration Lab, Institut Pasteur de Montevideo, Montevideo 11.400, Uruguay.
Source: Biotechnology reports (Amsterdam, Netherlands) [Biotechnol Rep (Amst)] 2026 Jan 12; Vol. 49, pp. e00946. Date of Electronic Publication: 2026 Jan 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B. V Country of Publication: Netherlands NLM ID: 101637426 Publication Model: eCollection Cited Medium: Print ISSN: 2215-017X (Print) Linking ISSN: 2215017X NLM ISO Abbreviation: Biotechnol Rep (Amst) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2215-017X
DOI:10.1016/j.btre.2026.e00946