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Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion.

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Title: Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion.
Authors: Zhou YF; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China., Yang SB; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China., Zhang F; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China., Sun XD; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China., Chang BH; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China., Li YN; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China., Wu JH; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China., Jin HJ; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China., Huang M; Department of Neurology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Hubei University of Chinese Medicine, Wuhan, China., Chen SC; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China., Yang H; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China., Zhu DY; Department of Clinic Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China., Menon BK; Department of Community Health Sciences, Department of Clinical Neurosciences, Department of Radiology, and Hotchkiss Brain Institute, University of Calgary, AB, Canada., Hu B; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Source: Theranostics [Theranostics] 2026 Jan 01; Vol. 16 (7), pp. 3577-3598. Date of Electronic Publication: 2026 Jan 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zhou+YF%22">Zhou YF</searchLink>; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.<br /><searchLink fieldCode="AU" term="%22Yang+SB%22">Yang SB</searchLink>; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.<br /><searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.<br /><searchLink fieldCode="AU" term="%22Sun+XD%22">Sun XD</searchLink>; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.<br /><searchLink fieldCode="AU" term="%22Chang+BH%22">Chang BH</searchLink>; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.<br /><searchLink fieldCode="AU" term="%22Li+YN%22">Li YN</searchLink>; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.<br /><searchLink fieldCode="AU" term="%22Wu+JH%22">Wu JH</searchLink>; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.<br /><searchLink fieldCode="AU" term="%22Jin+HJ%22">Jin HJ</searchLink>; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.<br /><searchLink fieldCode="AU" term="%22Huang+M%22">Huang M</searchLink>; Department of Neurology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Chen+SC%22">Chen SC</searchLink>; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.<br /><searchLink fieldCode="AU" term="%22Zhu+DY%22">Zhu DY</searchLink>; Department of Clinic Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.<br /><searchLink fieldCode="AU" term="%22Menon+BK%22">Menon BK</searchLink>; Department of Community Health Sciences, Department of Clinical Neurosciences, Department of Radiology, and Hotchkiss Brain Institute, University of Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Hu+B%22">Hu B</searchLink>; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
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