Individualized Atrophy-Based Prediction of Dementia Progression in Familial Frontotemporal Lobar Degeneration With Bayesian Linear Mixed-Effects Modeling.

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Title: Individualized Atrophy-Based Prediction of Dementia Progression in Familial Frontotemporal Lobar Degeneration With Bayesian Linear Mixed-Effects Modeling.
Authors: Dutt S; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Leichter D; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Cobigo Y; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Wolf A; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Kornak J; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Clark A; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Russell LL; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK., Bouzigues A; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK., Cash DM; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK., Bocchetta M; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK., Olzinski M; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Appleby B; Department of Neurology, Case Western Reserve University, Cleveland, OH, USA., Bayram E; Department of Neurology, University of Colorado, Aurora, CO, USA., Borroni B; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.; Molecular Markers Laboratory, Fatebenefratelli, IRCCS Istituto Centro San Giovanni di Dio, Brescia, Italy., Bozoki A; Department of Neurology, University of North Carolina, Chapel Hill, NC., Butler CR; Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, UK.; Department of Brain Sciences, Imperial College London, London, UK., Clark D; Department of Neurology, Indiana University, Indianapolis, IN., Convery RS; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK., Darby RR; Department of Neurology, Vanderbilt University, Nashville, TN., de Mendonça A; University of Lisbon, Lisbon, Portugal., Dickerson B; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Domoto-Reilly K; Department of Neurology, University of Washington, Seattle, WA., Ducharme S; Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.; Montreal Neurological Institute, McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada., Ferry-Bolder E; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK., Finger E; Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada., Foster PH; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK., Galasko DR; Department of Neurosciences, University of California - San Diego, La Jolla, CA., Galimberti D; Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy.; Centro Dino Ferrari, University of Milan, Milan, Italy., Gerhard A; Division of Psychology Communication and Human Neuroscience, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.; Department of Nuclear Medicine, Center for Translational Neuro- and Behavioral Sciences, University Medicine Essen, Essen, Germany.; Department of Geriatric Medicine, Klinikum Hochsauerland, Arnsberg, Germany., Ghoshal N; Departments of Neurology and Psychiatry, Washington University, School of Medicine, Washington University, St. Louis, MO., Graff C; Department of Neurobiology, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.; Unit for Hereditary Dementias, Karolinska University Hospital, Solna, Sweden., Graff-Radford N; Department of Neurology, Mayo Clinic, Jacksonville, FL., Grant IM; Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, IL., Hales CM; Department of Neurology, Emory University School of Medicine, Atlanta, GA., Honig LS; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY.; Department of Neurology, Columbia University, New York, NY.; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY., Hsiung GY; Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada., Huey ED; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY.; Department of Neurology, Columbia University, New York, NY.; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY., Irwin D; Department of Neurology and Penn Frontotemporal Degeneration Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Jiskoot LC; Department of Neurology, Erasmus Medical Centre, Rotterdam, The Netherlands., Kremers W; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN., Kwan JY; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD., Laforce R; Département des Sciences Neurologiques, Clinique Interdisciplinaire de Mémoire, Laval University, Quebec City, Quebec, Canada., Le Ber I; Paris Brain Institute, Sorbonne Université, Paris, France.; Département de Neurologie, Hôpital Pitié-Salpêtrière, Paris, France., Léger GC; Department of Neurosciences, University of California - San Diego, La Jolla, CA., Levin J; Department of Neurology, Ludwig-Maximilians Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany., Litvan I; Department of Neurosciences, University of California - San Diego, La Jolla, CA., Mackenzie IR; Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada., Masellis M; Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada., Mendez MF; Department of Neurology, University of California - Los Angeles, Los Angeles, CA., Moreno F; Department of Neurology, Cognitive Disorders Unit, Hospital Universitario Donostia, San Sebastian, Spain.; Neurosciences Area, Group of Neurodegenerative Diseases, Biogipuzkoa Health Research Institute, San Sebastian, Spain.; Center for Biomedical Research in Neurodegenerative Disease, Carlos III Health Institute, Madrid, Spain., Onyike C; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD., Otto M; Department of Neurology, University of Ulm, Ulm, Germany., Pascual B; Department of Neurology, Houston Methodist Research Institute, Houston, TX., Pressman P; Department of Neurology, University of Colorado, Aurora, CO, USA., Rademakers R; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; Department of Neuroscience, Mayo Clinic, Jacksonville, FL., Ramos EM; Department of Neurology, University of California - Los Angeles, Los Angeles, CA., Ritter A; Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV., Roberson ED; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL., Rowe JB; Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK., Sanchez-Valle R; Department of Neurology, Alzheimer's Disease and Other Cognitive Disorders Unit, University of Barcelona, Barcelona, Spain., Santana I; University Hospital of Coimbra Neurology Service, University of Coimbra, Coimbra, Portugal.; Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal., Seelaar H; Department of Neurology, Erasmus Medical Centre, Rotterdam, The Netherlands., Snyder A; Department of Neurology and Penn Frontotemporal Degeneration Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD., Sorbi S; Department of Neurofarba, University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Synofzik M; Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany., Tartaglia MC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada., Tiraboschi P; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., van Swieten JC; Department of Neurology, Erasmus Medical Centre, Rotterdam, The Netherlands., Vandebergh M; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Vandenberghe R; Department of Neurosciences, Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium.; Neurology Service, University Hospitals Leuven, Leuven, Belgium.; Leuven Brain Institute, Leuven, Belgium., Heuer HW; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Miller BL; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Seeley WW; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Gorno-Tempini ML; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Kramer JH; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Forsberg L; Department of Neurology, Mayo Clinic, Rochester, MN., Kantarci K; Department of Radiology, Mayo Clinic, Rochester, MN., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN., Boxer AL; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Rohrer JD; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK., Rosen HJ; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA., Staffaroni AM; Department of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco, San Francisco, CA.
Corporate Authors: FTD Prevention Initiative (FPI) investigators
Source: Annals of neurology [Ann Neurol] 2026 May; Vol. 99 (5), pp. 1315-1326. Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1531-8249
DOI:10.1002/ana.78167